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Mutation Report for: Y332A_human-BCHE

Y332A_human-BCHE
Gene_Locus|human-BCHE
Mode of mutation|Site directed mutagenesis
Amino Acid change|Y332A
Torpedo number|334
Summary|
Comment|p.Y332A Tyr332Ala (p.Y360A Tyr360Ala in primary sequence with 28 amino-acids signal peptide) Peripheral Anionic site;interraction 70(98)/332(360)
Kinetic parameters|none


References:
    Title: Probing the peripheral site of human butyrylcholinesterase
    Macdonald IR, Martin E, Rosenberry TL, Darvesh S
    Ref: Biochemistry, 51:7046, 2012 : PubMed

            

    Title: Interaction between the peripheral site residues of human butyrylcholinesterase, D70 and Y332, in binding and hydrolysis of substrates
    Masson P, Xie W, Froment MT, Levitsky V, Fortier PL, Albaret C, Lockridge O
    Ref: Biochimica & Biophysica Acta, 1433:281, 1999 : PubMed

            




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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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