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Mutation Report for: Y124F_human-ACHE

Mode of mutation|Site directed mutagenesis
Amino Acid change|Y124F
Torpedo number|121
Comment|p.Y124F Tyr124Phe (p.Y155F Tyr155Phe in primary sequence with 31 amino-acids signal peptide) oxime interaction;reactivation of tabun-inhibited human AChE. Unable to facilitate HI-6-mediated reactivation of tabun-hAChE. Induced a 2-2.5-fold enhancement of the bimolecular rate constant for K027 and HLo-7
Kinetic parameters|none

    Title: Reactivation of tabun-hAChE investigated by structurally analogous oximes and mutagenesis
    Artursson E, Akfur C, Hornberg A, Worek F, Ekstrom F
    Ref: Toxicology, 265:108, 2009 : PubMed


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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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