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Mutation Report for: Y124C_mouse-ACHE

Y124C_mouse-ACHE
Gene_Locus|mouse-ACHE
Mode of mutation|Site directed mutagenesis
Amino Acid change|Y124C
Torpedo number|121
Summary|
Comment|p.Y124C Tyr124Cys Peripheral Anionic Site;Omega loop conformation test incorporation of the fluorophore acrylodan
Kinetic parameters|none


References:
    Title: Inhibitors tethered near the acetylcholinesterase active site serve as molecular rulers of the peripheral and acylation sites
    Johnson JL, Cusack B, Hughes TF, McCullough EH, Fauq A, Romanovskis P, Spatola AF, Rosenberry TL
    Ref: Journal of Biological Chemistry, 278:38948, 2003 : PubMed

            

    Title: Nanosecond dynamics of the mouse acetylcholinesterase cys69-cys96 omega loop
    Shi J, Tai K, McCammon JA, Taylor P, Johnson DA
    Ref: Journal of Biological Chemistry, 278:30905, 2003 : PubMed

            

    Title: Inhibitors of different structure induce distinguishing conformations in the omega loop, Cys 69- Cys 96, of mouse acetylcholinesterase
    Shi J, Radic Z, Taylor P
    Ref: Journal of Biological Chemistry, 277:43301, 2002 : PubMed

            

    Title: Reversibly bound and covalently attached ligands induce conformational changes in the Omega loop, Cys 69-Cys 96, of mouse acetylcholinesterase
    Shi J, Boyd AE, Radic Z, Taylor P
    Ref: Journal of Biological Chemistry, 276:42196, 2001 : PubMed

            

    Title: Probing the active center Gorge of acetylcholinesterase by fluorophores Linked to substituted cysteines
    Boyd AE, Marnett AB, Wong L, Taylor P
    Ref: Journal of Biological Chemistry, 275:22401, 2000 : PubMed

            




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