Gene Locus : human-ACHE
Mode of mutation :
Disease :
Summary :
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification :
Torpedo_number : No torpedo number
Kinetic Parameter : Edrophonium_WT_human-ACHE, Paranitrophenylacetate_WT_human-ACHE, S-N-Propylthioacetate_WT_human-ACHE, 3,3-dimethylbutylthioacetate_WT_human-ACHE, Acetylthiocholine_WT_human-ACHE, Hexamethonium_WT_human-ACHE, BW284C51_WT_human-ACHE, Propidium_WT_human-ACHE, Decamethonium_WT_human-ACHE, Bambuterol_WT_human-ACHE, Tacrine_WT_human-ACHE, HuperzineA_WT_human-ACHE, Succinylcholine~Suxamethonium_WT_human-ACHE, Dibucaine_WT_human-ACHE, Butyrylthiocholine_WT_human-ACHE, Cocaine_WT_human-ACHE, Edrophonium_Y72N\/Y124Q\/W286A\/F295L\/F297V\/Y337A_human-ACHE, HuperzineA_Y72N\/Y124Q\/W286A\/F295L\/F297V\/Y337A_human-ACHE, Tacrine_Y72N\/Y124Q\/W286A\/F295L\/F297V\/Y337A_human-ACHE, Decamethonium_Y72N\/Y124Q\/W286A\/F295L\/F297V\/Y337A_human-ACHE
News : No news
Comment :
| Title : The 'aromatic patch' of three proximal residues in the human acetylcholinesterase active centre allows for versatile interaction modes with inhibitors - Ariel_1998_Biochem.J_335_95 |
| Author(s) : Ariel N , Ordentlich A , Barak D , Bino T , Velan B , Shafferman A |
| Ref : Biochemical Journal , 335 :95 , 1998 |
| Abstract : Ariel_1998_Biochem.J_335_95 |
| ESTHER : Ariel_1998_Biochem.J_335_95 |
| PubMedSearch : Ariel_1998_Biochem.J_335_95 |
| PubMedID: 9742217 |
| Title : Overlapping drug interaction sites of human butyrylcholinesterase dissected by site-directed mutagenesis - Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423 |
| Author(s) : Loewenstein-Lichtenstein Y , Glick D , Gluzman N , Sternfeld M , Zakut H , Soreq H |
| Ref : Molecular Pharmacology , 50 :1423 , 1996 |
| Abstract : Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423 |
| ESTHER : Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423 |
| PubMedSearch : Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423 |
| PubMedID: 8967962 |
| Gene_locus related to this paper: human-BCHE |
| Title : Contribution of aromatic moieties of tyrosine 133 and of the anionic subsite tryptophan 86 to catalytic efficiency and allosteric modulation of acetylcholinesterase - Ordentlich_1995_J.Biol.Chem_270_2082 |
| Author(s) : Ordentlich A , Barak D , Kronman C , Ariel N , Segall Y , Velan B , Shafferman A |
| Ref : Journal of Biological Chemistry , 270 :2082 , 1995 |
| Abstract : Ordentlich_1995_J.Biol.Chem_270_2082 |
| ESTHER : Ordentlich_1995_J.Biol.Chem_270_2082 |
| PubMedSearch : Ordentlich_1995_J.Biol.Chem_270_2082 |
| PubMedID: 7836436 |
| Title : Acetylcholinesterase peripheral anionic site degeneracy conferred by amino acid arrays sharing a common core - Barak_1994_J.Biol.Chem_269_6296 |
| Author(s) : Barak D , Kronman C , Ordentlich A , Ariel N , Bromberg A , Marcus D , Lazar A , Velan B , Shafferman A |
| Ref : Journal of Biological Chemistry , 269 :6296 , 1994 |
| Abstract : Barak_1994_J.Biol.Chem_269_6296 |
| ESTHER : Barak_1994_J.Biol.Chem_269_6296 |
| PubMedSearch : Barak_1994_J.Biol.Chem_269_6296 |
| PubMedID: 8119978 |
| Title : Substrate inhibition of acetylcholinesterase: residues affecting signal transduction from the surface to the catalytic center - Shafferman_1992_EMBO.J_11_3561 |
| Author(s) : Shafferman A , Velan B , Ordentlich A , Kronman C , Grosfeld H , Leitner M , Flashner Y , Cohen S , Barak D , Ariel N |
| Ref : EMBO Journal , 11 :3561 , 1992 |
| Abstract : Shafferman_1992_EMBO.J_11_3561 |
| ESTHER : Shafferman_1992_EMBO.J_11_3561 |
| PubMedSearch : Shafferman_1992_EMBO.J_11_3561 |
| PubMedID: 1396557 |
| Title : The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580----Ala mutant - Velan_1991_J.Biol.Chem_266_23977 |
| Author(s) : Velan B , Grosfeld H , Kronman C , Leitner M , Gozes Y , Lazar A , Flashner Y , Marcus D , Cohen S , Shafferman A |
| Ref : Journal of Biological Chemistry , 266 :23977 , 1991 |
| Abstract : Velan_1991_J.Biol.Chem_266_23977 |
| ESTHER : Velan_1991_J.Biol.Chem_266_23977 |
| PubMedSearch : Velan_1991_J.Biol.Chem_266_23977 |
| PubMedID: 1748670 |