Gene Locus : drome-ACHE
Mode of mutation : Site directed mutagenesis
Disease :
Summary : Binding of Triton X-100 studies no effect on Triton X-100 binding Marcel_2000_J.Biol.Chem_275_11603 || Insecticide sensitivity Boublik_2002_Protein.Eng_15_43 || Back door hypothesis enlarge back channel Nachon_2008_Febs.J_275_2659
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : Binding of Triton X-100 studies || Insecticide sensitivity || Back door hypothesis
Torpedo_number : 84
Kinetic Parameter : No kinetic parameter
News : APRIL-24-2008
Comment : p.Trp121Ala || p.W121A Trp121Ala Catalytic anionic site. Mutation W83A in mature protein. Numbering in Boublik et al. 2002 || Mutation W83A in mature protein. Numbering in Boublik et al. 2002
| Title : Conformational rigidity of cholinesterases allows for the prediction of combined effects in a particular double mutant - Stojan_2016_Chem.Biol.Interact_259_110 |
| Author(s) : Stojan J |
| Ref : Chemico-Biological Interactions , 259 :110 , 2016 |
| Abstract : Stojan_2016_Chem.Biol.Interact_259_110 |
| ESTHER : Stojan_2016_Chem.Biol.Interact_259_110 |
| PubMedSearch : Stojan_2016_Chem.Biol.Interact_259_110 |
| PubMedID: 27174135 |
| Title : Insights into substrate and product traffic in the Drosophila melanogaster acetylcholinesterase active site gorge by enlarging a back channel - Nachon_2008_FEBS.J_275_2659 |
| Author(s) : Nachon F , Stojan J , Fournier D |
| Ref : Febs J , 275 :2659 , 2008 |
| Abstract : Nachon_2008_FEBS.J_275_2659 |
| ESTHER : Nachon_2008_FEBS.J_275_2659 |
| PubMedSearch : Nachon_2008_FEBS.J_275_2659 |
| PubMedID: 18422651 |
| Title : Acetylcholinesterase engineering for detection of insecticide residues - Boublik_2002_Protein.Eng_15_43 |
| Author(s) : Boublik Y , Saint-Aguet P , Lougarre A , Arnaud M , Villatte F , Estrada-Mondaca S , Fournier D |
| Ref : Protein Engineering , 15 :43 , 2002 |
| Abstract : Boublik_2002_Protein.Eng_15_43 |
| ESTHER : Boublik_2002_Protein.Eng_15_43 |
| PubMedSearch : Boublik_2002_Protein.Eng_15_43 |
| PubMedID: 11842237 |
| Title : Exploration of the Drosophila acetylcholinesterase substrate activation site using a reversible inhibitor (Triton X-100) and mutated enzymes - Marcel_2000_J.Biol.Chem_275_11603 |
| Author(s) : Marcel V , Estrada-Mondaca S , Magne F , Stojan J , Klaebe A , Fournier D |
| Ref : Journal of Biological Chemistry , 275 :11603 , 2000 |
| Abstract : Marcel_2000_J.Biol.Chem_275_11603 |
| ESTHER : Marcel_2000_J.Biol.Chem_275_11603 |
| PubMedSearch : Marcel_2000_J.Biol.Chem_275_11603 |
| PubMedID: 10766776 |