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Mutation Report for: T284Q/P285S/L286I/S287H/V288I_human-BCHE

Mode of mutation|Site directed mutagenesis
Amino Acid change|T284Q/P285S/L286I/S287H/V288I
Torpedo number|286//287//288//289//290//286,287,288,289,290
Comment|p.T284Q/P285S/L286I/S287H/V288I Thr284Gln/Pro285Ser/Leu286Ile/Ser287His/Val288Ile (p.T312Q/P313S/L314I/S315H/V316I Thr312Gln/Pro313Ser/Leu314Ile/Ser315His/Val316Ile in primary sequence with 28 amino-acids signal peptide) Multiple amino acid substitutions in the acyl-binding loop 284-TPLSV-288 284-ThrProLeuSerVal-288 close to the active site. replaced by ProProLeuArgSer QSIHI clone 8. Slow self-reactivation after inhibition by paraoxon
Kinetic parameters|none

    Title: Microfluidic droplet platform for ultrahigh-throughput single-cell screening of biodiversity
    Terekhov SS, Smirnov IV, Stepanova AV, Bobik TV, Mokrushina YA, Ponomarenko NA, Belogurov AA, Jr., Rubtsova MP, Kartseva OV and Altman S <15 more author(s)>
    Ref: Proc Natl Acad Sci U S A, 114:2550, 2017 : PubMed


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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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