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Mutation Report for: T284N/P285K/L286S/S287N_human-BCHE

Mode of mutation|Site directed mutagenesis
Amino Acid change|T284N/P285K/L286S/S287N
Torpedo number|286//287//288//289//286,287,288,289
Comment|p.T284N/P285K/L286S/S287N Thr284Asn/Pro285Lys/Leu286Ser/Ser287Asn (p.T312N/P313K/L314S/S315N Thr312Asn/Pro313Lys/Leu314Ser/Ser315Asn in primary sequence with 28 amino-acids signal peptide) Multiple amino acid substitutions in the acyl-binding loop 284-TPLSV-288 284-ThrProLeuSerVal-288 close to the active site. replaced by ProProLeuArgSer QSIHI clone 13. Slow self-reactivation after inhibition by paraoxon
Kinetic parameters|none

    Title: Microfluidic droplet platform for ultrahigh-throughput single-cell screening of biodiversity
    Terekhov SS, Smirnov IV, Stepanova AV, Bobik TV, Mokrushina YA, Ponomarenko NA, Belogurov AA, Jr., Rubtsova MP, Kartseva OV and Altman S <15 more author(s)>
    Ref: Proc Natl Acad Sci U S A, 114:2550, 2017 : PubMed


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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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