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Mutation Report for: R92H_human-PLA2G7

Mode of mutation|Natural mutant
Amino Acid change|
Torpedo number|
    Comment|p.Arg92His CGC->CAC Common polymorphism; rs1805017
    Kinetic parameters|none

      Title: Association Lp-PLA2 Gene Polymorphisms with Coronary Heart Disease
      Ma S, Ding L, Cai M, Chen L, Yan B, Yang J
      Ref: Dis Markers, 2022:9775699, 2022 : PubMed


      Title: Interaction between nonsynonymous polymorphisms in PLA2G7 gene and smoking on the risk of coronary heart disease in a Chinese population
      Chi Y, Shi C, Zhang X, Xi Y
      Ref: J Thromb Thrombolysis, 46:125, 2018 : PubMed


      Title: Possible effects of lipoprotein-associated phospholipase A2 single-nucleotide polymorphisms on cardiovascular risk in patients with preeclampsia
      Gungor ZB, Tuten A, Ekmekci H, Ekmekci OB, Kucur M, Oncul M, Donma O, Madazli R, Sonmez H
      Ref: J Matern Fetal Neonatal Med, :1, 2017 : PubMed


      Title: Correlations Between LP-PLA2 Gene Polymorphisms and Susceptibility and Severity of Acute Pancreatitis in a Chinese Population
      Ma M, Zhai CX, Sun CX
      Ref: Genet Test Mol Biomarkers, 21:206, 2017 : PubMed


      Title: Associations between four types of single-nucleotide polymorphisms in PLA2G7 gene and clinical atherosclerosis: a meta-analysis
      Santoso A, Maulana R, Alzahra F, Maghfirah I, Putrinarita AD, Heriansyah T
      Ref: Am J Cardiovasc Dis, 7:122, 2017 : PubMed


      Title: Effect of the R92H and A379V genotypes of platelet-activating factor acetylhydrolase on its enzyme activity, oxidative stress and metabolic profile in Chinese women with polycystic ovary syndrome
      Zhang R, Song Q, Liu H, Bai H, Zhang Y, Liu Q, Guan L, Fan P
      Ref: Lipids Health Dis, 16:57, 2017 : PubMed


      Title: Nonsynonymous polymorphisms in PLA2G7 gene are associated with the risk of coronary heart disease in a southern Chinese population
      Hong M, Zhang M, Lu X
      Ref: Mamm Genome, 26:191, 2015 : PubMed


      Title: PLA2G7 gene polymorphisms and coronary heart disease risk: a meta-analysis
      Wang Q, Hao Y, Mo X, Wang L, Lu X, Huang J, Cao J, Li H, Gu D
      Ref: Thromb Res, 126:498, 2010 : PubMed


      Title: Genetic variants and haplotypes of lipoprotein associated phospholipase A2 and their influence on cardiovascular disease (The Ludwigshafen Risk and Cardiovascular Health Study)
      Hoffmann MM, Winkler K, Renner W, Winkelmann BR, Seelhorst U, Wellnitz B, Boehm BO, Marz W
      Ref: J Thromb Haemost, 7:41, 2009 : PubMed


      Title: Inter-individual variability of plasma PAF-acetylhydrolase activity in ARDS patients and PAFAH genotype
      Li S, Stuart L, Zhang Y, Meduri GU, Umberger R, Yates CR
      Ref: J Clin Pharm Ther, 34:447, 2009 : PubMed


      Title: Comprehensive genetic analysis of the platelet activating factor acetylhydrolase (PLA2G7) gene and cardiovascular disease in case-control and family datasets
      Sutton BS, Crosslin DR, Shah SH, Nelson SC, Bassil A, Hale AB, Haynes C, Goldschmidt-Clermont PJ, Vance JM and Hauser ER <3 more author(s)>
      Ref: Hum Mol Genet, 17:1318, 2008 : PubMed


      Title: Association of sixty-one non-synonymous polymorphisms in forty-one hypertension candidate genes with blood pressure variation and hypertension
      Kokubo Y, Tomoike H, Tanaka C, Banno M, Okuda T, Inamoto N, Kamide K, Kawano Y, Miyata T
      Ref: Hypertens Res, 29:611, 2006 : PubMed


      Title: Platelet-activating factor-acetylhydrolase and PAF-receptor gene haplotypes in relation to future cardiovascular event in patients with coronary artery disease
      Ninio E, Tregouet D, Carrier JL, Stengel D, Bickel C, Perret C, Rupprecht HJ, Cambien F, Blankenberg S, Tiret L
      Ref: Hum Mol Genet, 13:1341, 2004 : PubMed


      Title: The Ile198Thr and Ala379Val variants of plasmatic PAF-acetylhydrolase impair catalytical activities and are associated with atopy and asthma
      Kruse S, Mao XQ, Heinzmann A, Blattmann S, Roberts MH, Braun S, Gao PS, Forster J, Kuehr J and Deichmann KA <2 more author(s)>
      Ref: American Journal of Human Genetics, 66:1522, 2000 : PubMed


      Title: Systematic screening of the LDL-PLA2 gene for polymorphic variants and case-control analysis in schizophrenia
      Bell R, Collier DA, Rice SQ, Roberts GW, Macphee CH, Kerwin RW, Price J, Gloger IS
      Ref: Biochemical & Biophysical Research Communications, 241:630, 1997 : PubMed


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