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Mutation Report for: Q119Y_human-BCHE

Q119Y_human-BCHE
Gene_Locus|human-BCHE
Mode of mutation|Site directed mutagenesis
Amino Acid change|Q119Y
Torpedo number|121
Summary|
Comment|p.Q119Y Gln119Tyr (p.Q147Y Gln147Tyr in primary sequence with 28 amino-acids signal peptide) Peripheral Anionic Site, no role in substrate binding
Kinetic parameters|BW284C51_Q119Y_human-BCHE,
Butyrylthiocholine_Q119Y_human-BCHE,
Dibucaine_Q119Y_human-BCHE,
Solanine_Q119Y_human-BCHE,
Succinylcholine~Suxamethonium_Q119Y_human-BCHE,
Tacrine_Q119Y_human-BCHE


References:
    Title: Overlapping drug interaction sites of human butyrylcholinesterase dissected by site-directed mutagenesis
    Loewenstein-Lichtenstein Y, Glick D, Gluzman N, Sternfeld M, Zakut H, Soreq H
    Ref: Molecular Pharmacology, 50:1423, 1996 : PubMed

            

    Title: Asp7O in the peripheral anionic site of human butyrylcholinesterase
    Masson P, Froment MT, Bartels CF, Lockridge O
    Ref: European Journal of Biochemistry, 235:36, 1996 : PubMed

            

    Title: Peripheral Anionic Site of Wild-Type and Mutant Human Butyrylcholinesterase
    Masson P, Froment MT, Bartels CF, Lockridge O
    Ref: In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases, (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.:230, 1995 : PubMed

            




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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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