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Mutation Report for: P75L_drome-ACHE

Mode of mutation|Site directed mutagenesis
Amino Acid change|P75L
Torpedo number|39
Comment|p.P75L Pro75Leu AceIJ40 mutant is an heat-sensitive variant. In the homozygous condition, this mutation is lethal when animals are raised at restrictive temperatures, i.e. above 25 degrees C for AceIJ40. The amount of secreted acetylcholinesterase below the lethality threshold of around 25%
Kinetic parameters|none

    Title: Drosophila melanogaster acetylcholinesterase: identification and expression of two mutations responsible for cold- and heat-sensitive phenotypes
    Mutero A, Bride JM, Pralavorio M, Fournier D
    Ref: Molecular & General Genetics, 243:699, 1994 : PubMed


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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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