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Mutation Report for: L380R/F535K_human-ACHE

Mode of mutation|Site directed mutagenesis
Amino Acid change|L380R/F535K
Torpedo number|373//527//373,527
Comment|p.L380R/F535K Leu380Arg/Phe535Lys. hydrophilic mutations L380R/F535K at dimer interface prevent dimer formation. Monomer has similar structural and biochemical behavior to the dimer (VX inhibition and subsequent reactivation with HI-6)
Kinetic parameters|none

    Title: The structural and biochemical impacts of monomerizing human acetylcholinesterase
    Bester SM, Adipietro KA, Funk VL, Myslinski JM, Keul ND, Cheung J, Wilder PT, Wood ZA, Weber DJ and Pegan SD <1 more author(s)>
    Ref: Protein Science, 28:1106, 2019 : PubMed


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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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