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Mutation Report for: L115M_human-ACHE

Mode of mutation|Site directed mutagenesis
Amino Acid change|L115M
Torpedo number|112
Comment|p.L115M Leu115Met (p.L146M Leu146Met in primary sequence with 31 amino-acids signal peptide) mutation designed by -Protein Repair One Stop Shop- process for the production of active human acetylcholinesterase in a prokaryotic system. The mutation gives Met as in Torpedo californica AChE
Kinetic parameters|none

    Title: Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability
    Goldenzweig A, Goldsmith M, Hill SE, Gertman O, Laurino P, Ashani Y, Dym O, Unger T, Albeck S and Fleishman SJ <6 more author(s)>
    Ref: Mol Cell, 63:337, 2016 : PubMed


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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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