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Mutation Report for: I82M_musdo-ACHE

Mode of mutation|Natural mutant
Amino Acid change|I82M
Torpedo number|83
Comment|NO EFFECT. Sensitivity to fenitroxon. I82M corresponds to the noted I162M in the paper Kozaki_2001_Insect.Biochem.Mol.Biol_31_991. We do not count the signal peptide in order to be in accordance with the mutation numbering of Walsh_2001_Biochem.J_359_175 paper
Kinetic parameters|none

    Title: Propoxur resistance associated with insensitivity of acetylcholinesterase (AChE) in the housefly, Musca domestica (Diptera: Muscidae)
    You C, Shan C, Xin J, Li J, Ma Z, Zhang Y, Zeng X, Gao X
    Ref: Sci Rep, 10:8400, 2020 : PubMed


    Title: Cloning, mutagenesis, and expression of the acetylcholinesterase gene from a strain of Musca domestica; the change from a drug-resistant to a sensitive enzyme
    Kim CS, Kim WT, Boo KS, Kim SI
    Ref: Mol Cells, 15:208, 2003 : PubMed


    Title: Fenitroxon insensitive acetylcholinesterases of the housefly, Musca domestica associated with point mutations
    Kozaki T, Shono T, Tomita T, Kono Y
    Ref: Insect Biochemistry & Molecular Biology, 31:991, 2001 : PubMed


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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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