I5T_human-BCHE

General

Gene Locus : human-BCHE

Mode of mutation : Natural mutant

Disease :

Summary : Succinylcholine hydrolysis\;Natural mutation Succinylcholine hydrolysis\;Dell-Kuster_2015_Eur.J.Anaesthesiol_32_687

AAA Change :

Allelic Variant :

Risk Factor :

Inhibitor :

Structure :

Disease by interaction :

Interact Gene Locus :

Xenobiotic sensitivity : Defect in Suxamethonium hydrolysis

Modification : Succinylcholine hydrolysis

Torpedo_number : 6

Kinetic Parameter : No kinetic parameter

News : July-29-2015

Comment : p.I5T Ile5Thr (p.I33T Ile33Thr in primary sequence with 28 amino-acids signal peptide) Succinylcholine hydrolysis\; neuromuscular block duration in excess of 10min

References (1)

Title : Predictors of the variability in neuromuscular block duration following succinylcholine: A prospective, observational study - Dell-Kuster_2015_Eur.J.Anaesthesiol_32_687
Author(s) : Dell-Kuster S , Levano S , Burkhart CS , Lelais F , Zemp A , Schobinger E , Hampl K , Kindler C , Girard T
Ref : European Journal of Anaesthesiology , : , 2015
Abstract : Dell-Kuster_2015_Eur.J.Anaesthesiol_32_687
ESTHER : Dell-Kuster_2015_Eur.J.Anaesthesiol_32_687
PubMedSearch : Dell-Kuster_2015_Eur.J.Anaesthesiol_32_687
PubMedID: 26213905