Gene Locus : luccu-E3aest7
Mode of mutation : Site directed mutagenesis || Natural mutant
Disease :
Summary : OP-resistance search for OP hydrolase and MCE activities Heidari_2004_Insect.Biochem.Mol.Biol_34_353 || Pyrethroids hydrolysis search for Pyrethroids hydrolysis activities Heidari_2005_Insect.Biochem.Mol.Biol_35_597 || Pyrethroids hydrolysis Hydrolysis of individual isomers of fluorogenic pyrethroid analogs by mutant carboxylesterases Devonshire_2007_Insect.Biochem.Mol.Biol_37_891 || OP-resistance Mutant are resistant to OP insecticides, G137D is responsible for loss of E3's carboxylesterase activity,acquisition of OP hydrolase activity (E3-Rdz Diazinon and diethyl OP) Newcomb_1997_Proc.Natl.Acad.Sci.U.S.A_94_7464 || OP-resistance 2 G137D and 2 W251L haplotypes found in natural populations Newcomb_2005_J.Mol.Evol_60_207
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : OP-resistance || Pyrethroids hydrolysis
Torpedo_number : 119
Kinetic Parameter : No kinetic parameter
News : No news
Comment : p.Gly137Asp. In Cui et al. called also G151D in some insects enzymes tested by site directed mutagenesis: two lepidopteran species (Spodoptera litura, B. mori), two homopteran species (Aphis gossypii, Nilaparvata lugens), two coleopteran species (T. castaneum, Harmonia axyridis) and one hymenopteran species (A. mellifera)
| Title : Conformational Disorganization within the Active Site of a Recently Evolved Organophosphate Hydrolase Limits Its Catalytic Efficiency - Mabbitt_2016_Biochemistry_55_1408 |
| Author(s) : Mabbitt PD , Correy GJ , Meirelles T , Fraser NJ , Coote ML , Jackson CJ |
| Ref : Biochemistry , 55 :1408 , 2016 |
| Abstract : Mabbitt_2016_Biochemistry_55_1408 |
| ESTHER : Mabbitt_2016_Biochemistry_55_1408 |
| PubMedSearch : Mabbitt_2016_Biochemistry_55_1408 |
| PubMedID: 26881849 |
| Gene_locus related to this paper: luccu-E3aest7 |
| Title : Two single mutations commonly cause qualitative change of nonspecific carboxylesterases in insects - Cui_2011_Insect.Biochem.Mol.Biol_41_1 |
| Author(s) : Cui F , Lin Z , Wang H , Liu S , Chang H , Reeck G , Qiao C , Raymond M , Kang L |
| Ref : Insect Biochemistry & Molecular Biology , 41 :1 , 2011 |
| Abstract : Cui_2011_Insect.Biochem.Mol.Biol_41_1 |
| ESTHER : Cui_2011_Insect.Biochem.Mol.Biol_41_1 |
| PubMedSearch : Cui_2011_Insect.Biochem.Mol.Biol_41_1 |
| PubMedID: 20888910 |
| Gene_locus related to this paper: aphgo-cxest |
| Title : Hydrolysis of individual isomers of fluorogenic pyrethroid analogs by mutant carboxylesterases from Lucilia cuprina - Devonshire_2007_Insect.Biochem.Mol.Biol_37_891 |
| Author(s) : Devonshire AL , Heidari R , Huang HZ , Hammock BD , Russell RJ , Oakeshott JG |
| Ref : Insect Biochemistry & Molecular Biology , 37 :891 , 2007 |
| Abstract : Devonshire_2007_Insect.Biochem.Mol.Biol_37_891 |
| ESTHER : Devonshire_2007_Insect.Biochem.Mol.Biol_37_891 |
| PubMedSearch : Devonshire_2007_Insect.Biochem.Mol.Biol_37_891 |
| PubMedID: 17681228 |
| Gene_locus related to this paper: luccu-E3aest7 |
| Title : Amplification of DNA from preserved specimens shows blowflies were preadapted for the rapid evolution of insecticide resistance - Hartley_2006_Proc.Natl.Acad.Sci.U.S.A_103_8757 |
| Author(s) : Hartley CJ , Newcomb RD , Russell RJ , Yong CG , Stevens JR , Yeates DK , La Salle J , Oakeshott JG |
| Ref : Proc Natl Acad Sci U S A , 103 :8757 , 2006 |
| Abstract : Hartley_2006_Proc.Natl.Acad.Sci.U.S.A_103_8757 |
| ESTHER : Hartley_2006_Proc.Natl.Acad.Sci.U.S.A_103_8757 |
| PubMedSearch : Hartley_2006_Proc.Natl.Acad.Sci.U.S.A_103_8757 |
| PubMedID: 16723400 |
| Title : Hydrolysis of pyrethroids by carboxylesterases from Lucilia cuprina and Drosophila melanogaster with active sites modified by in vitro mutagenesis - Heidari_2005_Insect.Biochem.Mol.Biol_35_597 |
| Author(s) : Heidari R , Devonshire AL , Campbell BE , Dorrian SJ , Oakeshott JG , Russell RJ |
| Ref : Insect Biochemistry & Molecular Biology , 35 :597 , 2005 |
| Abstract : Heidari_2005_Insect.Biochem.Mol.Biol_35_597 |
| ESTHER : Heidari_2005_Insect.Biochem.Mol.Biol_35_597 |
| PubMedSearch : Heidari_2005_Insect.Biochem.Mol.Biol_35_597 |
| PubMedID: 15857765 |
| Gene_locus related to this paper: drome-EST23aes07 , luccu-E3aest7 |
| Title : Multiple mutations and gene duplications conferring organophosphorus insecticide resistance have been selected at the Rop-1 locus of the sheep blowfly, Lucilia cuprina - Newcomb_2005_J.Mol.Evol_60_207 |
| Author(s) : Newcomb RD , Gleeson DM , Yong CG , Russell RJ , Oakeshott JG |
| Ref : Journal of Molecular Evolution , 60 :207 , 2005 |
| Abstract : Newcomb_2005_J.Mol.Evol_60_207 |
| ESTHER : Newcomb_2005_J.Mol.Evol_60_207 |
| PubMedSearch : Newcomb_2005_J.Mol.Evol_60_207 |
| PubMedID: 15785849 |
| Gene_locus related to this paper: luccu-E3aest7 |
| Title : Hydrolysis of organophosphorus insecticides by in vitro modified carboxylesterase E3 from Lucilia cuprina - Heidari_2004_Insect.Biochem.Mol.Biol_34_353 |
| Author(s) : Heidari R , Devonshire AL , Campbell BE , Bell KL , Dorrian SJ , Oakeshott JG , Russell RJ |
| Ref : Insect Biochemistry & Molecular Biology , 34 :353 , 2004 |
| Abstract : Heidari_2004_Insect.Biochem.Mol.Biol_34_353 |
| ESTHER : Heidari_2004_Insect.Biochem.Mol.Biol_34_353 |
| PubMedSearch : Heidari_2004_Insect.Biochem.Mol.Biol_34_353 |
| PubMedID: 15041019 |
| Gene_locus related to this paper: luccu-E3aest7 |
| Title : Kinetic efficiency of mutant carboxylesterases implicated in organophosphate insecticide resistance - Devonshire_2003_Pestic.Biochem.Physiol_76_1 |
| Author(s) : Devonshire AL , Heidari R , Bell KL , Campbell PM , Campbell BE , Odgers WA , Oakeshott JG , Russell RJ |
| Ref : Pesticide Biochemistry and Physiology , 76 :1 , 2003 |
| Abstract : Devonshire_2003_Pestic.Biochem.Physiol_76_1 |
| ESTHER : Devonshire_2003_Pestic.Biochem.Physiol_76_1 |
| PubMedSearch : Devonshire_2003_Pestic.Biochem.Physiol_76_1 |
| PubMedID: |
| Gene_locus related to this paper: luccu-E3aest7 , musdo-EST23aes07 |
| Title : Two different amino acid substitutions in the ali-esterase, E3, confer alternative types of organophosphorus insecticide resistance in the sheep blowfly, Lucilia cuprina - Campbell_1998_Insect.Biochem.Mol.Biol_28_139 |
| Author(s) : Campbell PM , Newcomb RD , Russell RJ , Oakeshott JG |
| Ref : Insect Biochemistry & Molecular Biology , 28 :139 , 1998 |
| Abstract : Campbell_1998_Insect.Biochem.Mol.Biol_28_139 |
| ESTHER : Campbell_1998_Insect.Biochem.Mol.Biol_28_139 |
| PubMedSearch : Campbell_1998_Insect.Biochem.Mol.Biol_28_139 |
| PubMedID: |
| Gene_locus related to this paper: luccu-E3aest7 |
| Title : A single amino acid substitution converts a carboxylesterase to an organophosphorus hydrolase and confers insecticide resistance on a blowfly - Newcomb_1997_Proc.Natl.Acad.Sci.U.S.A_94_7464 |
| Author(s) : Newcomb RD , Campbell PM , Ollis DL , Cheah E , Russell RJ , Oakeshott JG |
| Ref : Proceedings of the National Academy of Sciences of the United States of America , 94 :7464 , 1997 |
| Abstract : Newcomb_1997_Proc.Natl.Acad.Sci.U.S.A_94_7464 |
| ESTHER : Newcomb_1997_Proc.Natl.Acad.Sci.U.S.A_94_7464 |
| PubMedSearch : Newcomb_1997_Proc.Natl.Acad.Sci.U.S.A_94_7464 |
| PubMedID: 9207114 |
| Gene_locus related to this paper: luccu-ACHE , luccu-E3aest7 |