Gene Locus : human-BCHE
Mode of mutation : Site directed mutagenesis
Disease :
Summary : Oxyanion hole lowest kcat Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423 || Search for phosphotriesterase activity Phosphotriesterase activity OP sensitive Schopfer_2004_J.Med.Chem.Biol.Radiol.Def_2_1
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : Oxyanion hole || Search for phosphotriesterase activity
Torpedo_number : 119
Kinetic Parameter : Butyrylthiocholine_G117D_human-BCHE
News : No news
Comment : p.G117D Gly117Asp (p.G145D Gly145Asp in primary sequence with 28 amino-acids signal peptide)Oxyanion hole\;lowest kcat
| Title : Mutants of human butyrylcholinesterase with organophosphate hydrolase activity\; evidence that His117 is a general base catalyst for hydrolysis of echothiophate - Schopfer_2004_J.Med.Chem.Biol.Radiol.Def_2_1 |
| Author(s) : Schopfer LM , Boeck AT , Broomfield CA , Lockridge O |
| Ref : Journal of Medicinal Chemistryical Biology Radiol Def , 2 :1 , 2004 |
| Abstract : Schopfer_2004_J.Med.Chem.Biol.Radiol.Def_2_1 |
| ESTHER : Schopfer_2004_J.Med.Chem.Biol.Radiol.Def_2_1 |
| PubMedSearch : Schopfer_2004_J.Med.Chem.Biol.Radiol.Def_2_1 |
| PubMedID: |
| Title : Overlapping drug interaction sites of human butyrylcholinesterase dissected by site-directed mutagenesis - Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423 |
| Author(s) : Loewenstein-Lichtenstein Y , Glick D , Gluzman N , Sternfeld M , Zakut H , Soreq H |
| Ref : Molecular Pharmacology , 50 :1423 , 1996 |
| Abstract : Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423 |
| ESTHER : Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423 |
| PubMedSearch : Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423 |
| PubMedID: 8967962 |
| Gene_locus related to this paper: human-BCHE |