Gene Locus : drome-ACHE
Mode of mutation : Natural mutant || Site directed mutagenesis
Disease :
Summary : Insecticide sensitivity Boublik_2002_Protein.Eng_15_43 || OP-resistance Fournier_1992_J.Biol.Chem_267_14270 || OP-resistance Morton_1982_Biochem.Genet_20_179
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : Insecticide sensitivity || OP-resistance
Torpedo_number : 290
Kinetic Parameter : No kinetic parameter
News : No news
Comment : Point mutation responsible for the malathion resistance in the MH19 strain isolated by Morton and Singh 1982 Transformant with a minigenebearing this mutations give malathion resistance || Mutation F330A in mature protein. Numbering in Boublik et al. 2002 || p.Phe3683Ala
| Title : Acetylcholinesterase engineering for detection of insecticide residues - Boublik_2002_Protein.Eng_15_43 |
| Author(s) : Boublik Y , Saint-Aguet P , Lougarre A , Arnaud M , Villatte F , Estrada-Mondaca S , Fournier D |
| Ref : Protein Engineering , 15 :43 , 2002 |
| Abstract : Boublik_2002_Protein.Eng_15_43 |
| ESTHER : Boublik_2002_Protein.Eng_15_43 |
| PubMedSearch : Boublik_2002_Protein.Eng_15_43 |
| PubMedID: 11842237 |
| Title : Acetylcholinesterase. Two types of modifications confer resistance to insecticide - Fournier_1992_J.Biol.Chem_267_14270 |
| Author(s) : Fournier D , Bride JM , Hoffmann F , Karch F |
| Ref : Journal of Biological Chemistry , 267 :14270 , 1992 |
| Abstract : Fournier_1992_J.Biol.Chem_267_14270 |
| ESTHER : Fournier_1992_J.Biol.Chem_267_14270 |
| PubMedSearch : Fournier_1992_J.Biol.Chem_267_14270 |
| PubMedID: 1629220 |
| Title : The association between malathion resistance and acetylcholinesterase in Drosophila melanogaster - Morton_1982_Biochem.Genet_20_179 |
| Author(s) : Morton RA , Singh RS |
| Ref : Biochemical Genetics , 20 :179 , 1982 |
| Abstract : Morton_1982_Biochem.Genet_20_179 |
| ESTHER : Morton_1982_Biochem.Genet_20_179 |
| PubMedSearch : Morton_1982_Biochem.Genet_20_179 |
| PubMedID: 6807282 |