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Mutation Report for: F358S_9cucu-ACHE1

F358S_9cucu-ACHE1
Gene_Locus|9cucu-ACHE1
Mode of mutation|Natural mutant
Amino Acid change|F358S
Torpedo number|290
Summary|
Comment|Five AA in the ace1 of R P. japonica differed from those found in S P. japonica. F358S, located in the acyl-binding pocket, might play a crucial role in the resistance of the insect to organophosphates (OPs). Others: K493E and I538V, close to conserved aromatic amino acids (i.e., H509, Y511, and W499) in the gorge, and G571R and T576A
Kinetic parameters|none


References:
    Title: Identification and characterization of ace1-type acetylcholinesterase in insecticide-resistant and -susceptible Propylaea japonica (Thunberg)
    Wang MM, Xing LY, Ni ZW, Wu G
    Ref: Bull Entomol Res, :1, 2017 : PubMed

            




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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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