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Mutation Report for: F297I_mouse-ACHE

Mode of mutation|Site directed mutagenesis
Amino Acid change|F297I
Torpedo number|290
Comment|enlargement of the active site of the gorge
Kinetic parameters|Acetylthiocholine_F297I_mouse-ACHE,

    Title: Mutation of acetylcholinesterase to enhance oxime-assisted catalytic turnover of methylphosphonates
    Kovarik Z, Radic Z, Berman HA, Taylor P
    Ref: Toxicology, 233:79, 2007 : PubMed


    Title: Active site mutant acetylcholinesterase interactions with 2-PAM, HI-6, and DDVP
    Kovarik Z, Ciban N, Radic Z, Simeon-Rudolf V, Taylor P
    Ref: Biochemical & Biophysical Research Communications, 342:973, 2006 : PubMed


    Title: Aromatic amino-acid residues at the active and peripheral anionic sites control the binding of E2020 (Aricept) to cholinesterases
    Saxena A, Fedorko JM, Vinayaka CR, Medhekar R, Radic Z, Taylor P, Lockridge O, Doctor BP
    Ref: European Journal of Biochemistry, 270:4447, 2003 : PubMed


    Title: Inactivation studies of acetylcholinesterase with phenylmethylsulfonyl fluoride
    Kraut D, Goff H, Pai RK, Hosea NA, Silman I, Sussman JL, Taylor P, Voet JG
    Ref: Molecular Pharmacology, 57:1243, 2000 : PubMed


    Title: Amino acid residues involved in the interaction of acetylcholinesterase and butyrylcholinesterase with the carbamates Ro 02-0683 and bambuterol, and with terbutaline
    Kovarik Z, Radic Z, Grgas B, Skrinjaric-Spoljar M, Reiner E, Simeon-Rudolf V
    Ref: Biochimica & Biophysica Acta, 1433:261, 1999 : PubMed


    Title: Specificity and orientation of trigonal carboxyl esters and tetrahedral alkylphosphonyl esters in cholinesterases
    Hosea NA, Berman HA, Taylor P
    Ref: Biochemistry, 34:11528, 1995 : PubMed


    Title: Organophosphate Specificity of Acyl Pocket Cholinesterase Mutants
    Pickering NA, Taylor P, Berman HA
    Ref: In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases, (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.:227, 1995 : PubMed


    Title: Site of fasciculin interaction with acetylcholinesterase
    Radic Z, Duran R, Vellom DC, Li Y, Cervenansky C, Taylor P
    Ref: Journal of Biological Chemistry, 269:11233, 1994 : PubMed


    Title: Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors
    Radic Z, Pickering NA, Vellom DC, Camp S, Taylor P
    Ref: Biochemistry, 32:12074, 1993 : PubMed


    Title: Amino acid residues controlling acetylcholinesterase and butyrylcholinesterase specificity
    Vellom DC, Radic Z, Li Y, Pickering NA, Camp S, Taylor P
    Ref: Biochemistry, 32:12, 1993 : PubMed


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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