Gene Locus : mouse-ACHE
Mode of mutation : Site directed mutagenesis
Disease :
Summary : Acyl specificity Acyl pocket decreases km and kcat for ACT Radic_1993_Biochemistry_32_12074 Pickering_1995_5th.ChE.Meeting.Madras__227
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : Acyl specificity
Torpedo_number : 288
Kinetic Parameter : Acetylthiocholine_F295Y_mouse-ACHE, Butyrylthiocholine_F295Y_mouse-ACHE, Benzoylthiocholine_F295Y_mouse-ACHE
News : No news
Comment : p.Phe295Tyr
| Title : Organophosphate Specificity of Acyl Pocket Cholinesterase Mutants - |
| Author(s) : Pickering NA , Taylor P , Berman HA |
| Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :227 , 1995 |
| PubMedID: |
| Title : Specificity and orientation of trigonal carboxyl esters and tetrahedral alkylphosphonyl esters in cholinesterases - Hosea_1995_Biochemistry_34_11528 |
| Author(s) : Hosea NA , Berman HA , Taylor P |
| Ref : Biochemistry , 34 :11528 , 1995 |
| Abstract : Hosea_1995_Biochemistry_34_11528 |
| ESTHER : Hosea_1995_Biochemistry_34_11528 |
| PubMedSearch : Hosea_1995_Biochemistry_34_11528 |
| PubMedID: 7547883 |
| Title : Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors - Radic_1993_Biochemistry_32_12074 |
| Author(s) : Radic Z , Pickering NA , Vellom DC , Camp S , Taylor P |
| Ref : Biochemistry , 32 :12074 , 1993 |
| Abstract : Radic_1993_Biochemistry_32_12074 |
| ESTHER : Radic_1993_Biochemistry_32_12074 |
| PubMedSearch : Radic_1993_Biochemistry_32_12074 |
| PubMedID: 8218285 |