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Mutation Report for: F295L/Y337A_mouse-ACHE

Mode of mutation|Site directed mutagenesis
Amino Acid change|F295L/Y337A
Torpedo number|330//288//288,330
Comment|enlargement of the active site of the gorge to enhance oxime-assisted catalytic turnover of OP
Kinetic parameters|none

    Title: Reactivation of Tabun-inhibited Acetylcholinesterase Investigated by Two Oximes and Mutagenesis
    Katalinic M, Kovarik Z
    Ref: Croatica Chemica Acta, 85:209", 2012 : PubMed


    Title: Mutation of acetylcholinesterase to enhance oxime-assisted catalytic turnover of methylphosphonates
    Kovarik Z, Radic Z, Berman HA, Taylor P
    Ref: Toxicology, 233:79, 2007 : PubMed


    Title: Active site mutant acetylcholinesterase interactions with 2-PAM, HI-6, and DDVP
    Kovarik Z, Ciban N, Radic Z, Simeon-Rudolf V, Taylor P
    Ref: Biochemical & Biophysical Research Communications, 342:973, 2006 : PubMed


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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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