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Mutation Report for: F295L/F338A_human-ACHE

Mode of mutation|Site directed mutagenesis
Amino Acid change|F295L/F338A
Torpedo number|331,288//331//288
Comment|p.F295L/F338A Phe295Leu/Phe338Ala (p.F326L/F369A Phe326Leu/Phe369Ala in primary sequence with 31 amino-acids signal peptide) Acyl specificity;Acyl pocket 55-fold decreased catalytic activity, orientation of His 447
Kinetic parameters|none

    Title: Oxime-assisted acetylcholinesterase catalytic scavengers of organophosphates that resist aging
    Cochran R, Kalisiak J, Kucukkilinc TT, Radic Z, Garcia E, Zhang L, Ho KY, Amitai G, Kovarik Z and Taylor P <2 more author(s)>
    Ref: Journal of Biological Chemistry, 286:29718, 2011 : PubMed


    Title: Functional requirements for the optimal catalytic configuration of the AChE active center
    Shafferman A, Barak D, Kaplan D, Ordentlich A, Kronman C, Velan B
    Ref: Chemico-Biological Interactions, 157-158:123, 2005 : PubMed


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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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