Kinetic parameters

Tree Display

AceDB Schema

XML Display


Mutation Report for: E197D_human-BCHE

Mode of mutation|Site directed mutagenesis
Amino Acid change|E197D
Torpedo number|199
Comment|p.E197D Glu197Asp (p.E225D Glu225Asp in primary sequence with 28 amino-acids signal peptide) moderatly reduced substrate activation; increases half-life of aging by DFP 5.8 times
Kinetic parameters|none

    Title: Effects of mutations of active site residues and amino acids interacting with the Omega loop on substrate activation of butyrylcholinesterase
    Masson P, Xie W, Froment MT, Lockridge O
    Ref: Biochimica & Biophysica Acta, 1544:166, 2001 : PubMed


    Title: Structural and hydration changes in the active site gorge of phosporhylated butyrylcholinesterase accompanying the aging process
    Masson P, Fortier PL, Albaret C, Clery C, Guerra P, Lockridge O
    Ref: Chemico-Biological Interactions, 119-120:17, 1999 : PubMed


    Title: Aging of di-isopropyl-phosphorylated human butyrylcholinesterase
    Masson P, Fortier PL, Albaret C, Froment MT, Bartels CF, Lockridge O
    Ref: Biochemical Journal, 327 ( Pt 2):601, 1997 : PubMed


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page

Acknowledgements and disclaimer