Gene Locus : mouse-ACHE
Mode of mutation : Site directed mutagenesis
Disease :
Summary : Peripheral Anionic Site increase Km ACTh slight dim kcat Radic_1993_Biochemistry_32_12074 Radic_1994_J.Biol.Chem_269_11233 || Electrostatic D74N contribute the most to ligand trapping or orientation Radic_1997_J.Biol.Chem_272_23265 || Aricept~Donepezil~E2020 inhibition 2300 fold increase Ki vs WT Saxena_2003_Eur.J.Biochem_270_4447
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : Peripheral Anionic Site || Electrostatic || Aricept~Donepezil~E2020 inhibition
Torpedo_number : 72
Kinetic Parameter : Acetylthiocholine_D74N_mouse-ACHE, BW284C51_D74N_mouse-ACHE, Propidium_D74N_mouse-ACHE, Decamethonium_D74N_mouse-ACHE, WT-fasciculin2_D74N_mouse-ACHE
News : No news
Comment : p.Asp74Asn
| Title : Aromatic amino-acid residues at the active and peripheral anionic sites control the binding of E2020 (Aricept) to cholinesterases - Saxena_2003_Eur.J.Biochem_270_4447 |
| Author(s) : Saxena A , Fedorko JM , Vinayaka CR , Medhekar R , Radic Z , Taylor P , Lockridge O , Doctor BP |
| Ref : European Journal of Biochemistry , 270 :4447 , 2003 |
| Abstract : Saxena_2003_Eur.J.Biochem_270_4447 |
| ESTHER : Saxena_2003_Eur.J.Biochem_270_4447 |
| PubMedSearch : Saxena_2003_Eur.J.Biochem_270_4447 |
| PubMedID: 14622273 |
| Title : Reversible inhibition of acetylcholinesterase and butyrylcholinesterase by 4,4'-bipyridine and by a coumarin derivative - Simeon-Rudolf_1999_Chem.Biol.Interact_119-120_119 |
| Author(s) : Simeon-Rudolf V , Kovarik Z , Radic Z , Reiner E |
| Ref : Chemico-Biological Interactions , 119-120 :119 , 1999 |
| Abstract : Simeon-Rudolf_1999_Chem.Biol.Interact_119-120_119 |
| ESTHER : Simeon-Rudolf_1999_Chem.Biol.Interact_119-120_119 |
| PubMedSearch : Simeon-Rudolf_1999_Chem.Biol.Interact_119-120_119 |
| PubMedID: 10421445 |
| Title : Amino acid residues involved in the interaction of acetylcholinesterase and butyrylcholinesterase with the carbamates Ro 02-0683 and bambuterol, and with terbutaline - Kovarik_1999_Biochim.Biophys.Acta_1433_261 |
| Author(s) : Kovarik Z , Radic Z , Grgas B , Skrinjaric-Spoljar M , Reiner E , Simeon-Rudolf V |
| Ref : Biochimica & Biophysica Acta , 1433 :261 , 1999 |
| Abstract : Kovarik_1999_Biochim.Biophys.Acta_1433_261 |
| ESTHER : Kovarik_1999_Biochim.Biophys.Acta_1433_261 |
| PubMedSearch : Kovarik_1999_Biochim.Biophys.Acta_1433_261 |
| PubMedID: 10446376 |
| Title : Role of edrophonium in prevention of the re-inhibition of acetylcholinesterase by phosphorylated oxime - Luo_1999_Chem.Biol.Interact_119-120_129 |
| Author(s) : Luo C , Saxena A , Ashani Y , Leader H , Radic Z , Taylor P , Doctor BP |
| Ref : Chemico-Biological Interactions , 119-120 :129 , 1999 |
| Abstract : Luo_1999_Chem.Biol.Interact_119-120_129 |
| ESTHER : Luo_1999_Chem.Biol.Interact_119-120_129 |
| PubMedSearch : Luo_1999_Chem.Biol.Interact_119-120_129 |
| PubMedID: 10421446 |
| Title : Electrostatic influence on the kinetics of ligand binding to acetylcholinesterase. Distinctions between active center ligands and fasciculin - Radic_1997_J.Biol.Chem_272_23265 |
| Author(s) : Radic Z , Kirchhoff PD , Quinn DM , McCammon JA , Taylor P |
| Ref : Journal of Biological Chemistry , 272 :23265 , 1997 |
| Abstract : Radic_1997_J.Biol.Chem_272_23265 |
| ESTHER : Radic_1997_J.Biol.Chem_272_23265 |
| PubMedSearch : Radic_1997_J.Biol.Chem_272_23265 |
| PubMedID: 9287336 |
| Title : Site of fasciculin interaction with acetylcholinesterase - Radic_1994_J.Biol.Chem_269_11233 |
| Author(s) : Radic Z , Duran R , Vellom DC , Li Y , Cervenansky C , Taylor P |
| Ref : Journal of Biological Chemistry , 269 :11233 , 1994 |
| Abstract : Radic_1994_J.Biol.Chem_269_11233 |
| ESTHER : Radic_1994_J.Biol.Chem_269_11233 |
| PubMedSearch : Radic_1994_J.Biol.Chem_269_11233 |
| PubMedID: 8157652 |
| Title : Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors - Radic_1993_Biochemistry_32_12074 |
| Author(s) : Radic Z , Pickering NA , Vellom DC , Camp S , Taylor P |
| Ref : Biochemistry , 32 :12074 , 1993 |
| Abstract : Radic_1993_Biochemistry_32_12074 |
| ESTHER : Radic_1993_Biochemistry_32_12074 |
| PubMedSearch : Radic_1993_Biochemistry_32_12074 |
| PubMedID: 8218285 |