Mutation Report for: D74N/Y341A_human-ACHED74N/Y341A_human-ACHE Gene_Locus | | | human-ACHE |
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Mode of mutation | | | Site directed mutagenesis |
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Amino Acid change | | | D74N/Y341A |
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Torpedo number | | | 72,334//334//72 |
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Summary | | | |
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Comment | | | p.D74N/Y341A Asp74Gln/Tyr341Ala (p.D105N/Y372A Asp105Gln/Tyr372Ala in primary sequence with 31 amino-acids signal peptide) Peripheral Anionic Site;no cooperativity D74 Y341 |
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Kinetic parameters | | | none |
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References:
Title: Molecular Aspects of Catalysis and of Allosteric Regulation of Aceytlcholinesterases
Shafferman A, Ordentlich A, Barak D, Kronman C, Ariel N, Leitner M, Segall Y, Bromberg A, Reuveny S and Velan B <4 more author(s)>
Shafferman A, Ordentlich A, Barak D, Kronman C, Ariel N, Leitner M, Segall Y, Bromberg A, Reuveny S, Marcus D, Bino T, Lazar A, Cohen S, Velan B (- 4)
Ref: In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases, (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.:189, 1995 : PubMed
        
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