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Mutation Report for: A507E_human-ACHE

Mode of mutation|Site directed mutagenesis
Amino Acid change|A507E
Torpedo number|499
Comment|p.A507E Ala507Glu (p.A538E Ala538Glu in primary sequence with 31 amino-acids signal peptide) mutation designed by -Protein Repair One Stop Shop- process for the production of active human acetylcholinesterase in a prokaryotic system. The mutation gives Glu as in Torpedo californica AChE and Human BCHE
Kinetic parameters|none

    Title: Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability
    Goldenzweig A, Goldsmith M, Hill SE, Gertman O, Laurino P, Ashani Y, Dym O, Unger T, Albeck S and Fleishman SJ <6 more author(s)>
    Ref: Mol Cell, 63:337, 2016 : PubMed


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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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