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Mutation Report for: A280T_tetur-ACHE

Mode of mutation|Natural mutant
Amino Acid change|A280T
Torpedo number|280
Comment|Khajehali et al. found this modification in all three OP strains but not all clones. This mutation does not seem to be responsible for the modification of the biochemical properties of AChE1. This residue is not conserved among species and both resistant and susceptible strains of T. urticae from Japan have a T at position 280. Kwon et al. present evidences that A280T reduce OP sensitivity of AChE and contribute to resistance. The amino acid substitution was modified accordingly in the database
Kinetic parameters|none

    Title: Geographical distribution and origin of acetylcholinesterase mutations conferring acaricide resistance in Tetranychus urticae populations from Turkey
    Inak E
    Ref: Exp Appl Acarol, :, 2021 : PubMed


    Title: Identification and characterization of striking multiple-insecticide resistance in a Tetranychus urticae field population from Greece
    Papapostolou KM, Riga M, Charamis J, Skoufa E, Souchlas V, Ilias A, Dermauw W, Ioannidis P, Van Leeuwen T, Vontas J
    Ref: Pest Manag Sci, 77:666, 2021 : PubMed


    Title: Global distribution and origin of target site insecticide resistance mutations in Tetranychus urticae
    Ilias A, Vontas J, Tsagkarakou A
    Ref: Insect Biochemistry & Molecular Biology, 48:17, 2014 : PubMed


    Title: The overexpression of acetylcholinesterase compensates for the reduced catalytic activity caused by resistance-conferring mutations in Tetranychus urticae
    Kwon DH, Choi JY, Je YH, Lee SH
    Ref: Insect Biochemistry & Molecular Biology, 42:212, 2012 : PubMed


    Title: Acetylcholinesterase point mutations in European strains of Tetranychus urticae (Acari: Tetranychidae) resistant to organophosphates
    Khajehali J, Van Leeuwen T, Grispou M, Morou E, Alout H, Weill M, Tirry L, Vontas J, Tsagkarakou A
    Ref: Pest Manag Sci, 66:220, 2010 : PubMed


    Title: Acetylcholinesterase point mutations putatively associated with monocrotophos resistance in the two-spotted spider mite
    Kwon DH, Im JS, Ahn JJ, Lee J-H, Clark JM, Lee SH
    Ref: Pesticide Biochemistry and Physiology, 96:36, 2010 : PubMed


    Title: Extensive gene duplication of acetylcholinesterase associated with organophosphate resistance in the two-spotted spider mite
    Kwon DH, Clark JM, Lee SH
    Ref: Insect Molecular Biology, 19:195, 2010 : PubMed


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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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