Gene Locus : human-LIPC
Mode of mutation : Natural mutant
Disease :
Summary :
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification :
Torpedo_number : No torpedo number
Kinetic Parameter : No kinetic parameter
News : No news
Comment : The C-->T(-480) allele is associated with lower HL -480C\/T
| Title : Age-dependent association between hepatic lipase gene C-480T polymorphism and the risk of pre-hospital sudden cardiac death: the Helsinki Sudden Death Study - Fan_2007_Atherosclerosis_192_421 |
| Author(s) : Fan YM , Lehtimaki T , Rontu R , Ilveskoski E , Goebeler S , Kajander O , Mikkelsson J , Perola M , Karhunen PJ |
| Ref : Atherosclerosis , 192 :421 , 2007 |
| Abstract : Fan_2007_Atherosclerosis_192_421 |
| ESTHER : Fan_2007_Atherosclerosis_192_421 |
| PubMedSearch : Fan_2007_Atherosclerosis_192_421 |
| PubMedID: 16793047 |
| Title : The -250G-->A polymorphism in the human hepatic lipase gene promoter affects blood lipids in Chinese - Zhao_2006_Clin.Chim.Acta_365_149 |
| Author(s) : Zhao S , Xie X , Nie S |
| Ref : Clinica Chimica Acta , 365 :149 , 2006 |
| Abstract : Zhao_2006_Clin.Chim.Acta_365_149 |
| ESTHER : Zhao_2006_Clin.Chim.Acta_365_149 |
| PubMedSearch : Zhao_2006_Clin.Chim.Acta_365_149 |
| PubMedID: 16153627 |
| Title : The C-480T hepatic lipase polymorphism is associated with HDL-C but not with risk of coronary heart disease - McCaskie_2006_Clin.Genet_70_114 |
| Author(s) : McCaskie PA , Cadby G , Hung J , McQuillan BM , Chapman CM , Carter KW , Thompson PL , Palmer LJ , Beilby JP |
| Ref : Clin Genet , 70 :114 , 2006 |
| Abstract : McCaskie_2006_Clin.Genet_70_114 |
| ESTHER : McCaskie_2006_Clin.Genet_70_114 |
| PubMedSearch : McCaskie_2006_Clin.Genet_70_114 |
| PubMedID: 16879193 |
| Title : The influence of hepatic lipase C-480T polymorphism on coronary flow reserve in young men is independent of the plasma cholesterol level - Fan_2006_Atherosclerosis_188_391 |
| Author(s) : Fan YM , Laaksonen R , Janatuinen T , Vesalainen R , Laine H , Raitakari OT , Nuutila P , Knuuti J , Rontu R , Lehtimaki T |
| Ref : Atherosclerosis , 188 :391 , 2006 |
| Abstract : Fan_2006_Atherosclerosis_188_391 |
| ESTHER : Fan_2006_Atherosclerosis_188_391 |
| PubMedSearch : Fan_2006_Atherosclerosis_188_391 |
| PubMedID: 16330034 |
| Title : Interactions of dietary fat intake and the hepatic lipase -480C-->T polymorphism in determining hepatic lipase activity: the Hoorn Study - Bos_2005_Am.J.Clin.Nutr_81_911 |
| Author(s) : Bos G , Dekker JM , Feskens EJ , Ocke MC , Nijpels G , Stehouwer CD , Bouter LM , Heine RJ , Jansen H |
| Ref : Am J Clin Nutr , 81 :911 , 2005 |
| Abstract : Bos_2005_Am.J.Clin.Nutr_81_911 |
| ESTHER : Bos_2005_Am.J.Clin.Nutr_81_911 |
| PubMedSearch : Bos_2005_Am.J.Clin.Nutr_81_911 |
| PubMedID: 15817871 |
| Title : Hepatic lipase C-480T genotype-dependent benefit from long-term hormone replacement therapy for atherosclerosis progression in postmenopausal women - Fan_2005_J.Clin.Endocrinol.Metab_90_3786 |
| Author(s) : Fan YM , Dastidar P , Jokela H , Punnonen R , Lehtimaki T |
| Ref : J Clinical Endocrinology Metab , 90 :3786 , 2005 |
| Abstract : Fan_2005_J.Clin.Endocrinol.Metab_90_3786 |
| ESTHER : Fan_2005_J.Clin.Endocrinol.Metab_90_3786 |
| PubMedSearch : Fan_2005_J.Clin.Endocrinol.Metab_90_3786 |
| PubMedID: 15755868 |
| Title : Influence of common variants in the CETP, LPL, HL and APO E genes on LDL heterogeneity in healthy, middle-aged men - Skoglund-Andersson_2003_Atherosclerosis_167_311 |
| Author(s) : Skoglund-Andersson C , Ehrenborg E , Fisher RM , Olivecrona G , Hamsten A , Karpe F |
| Ref : Atherosclerosis , 167 :311 , 2003 |
| Abstract : Skoglund-Andersson_2003_Atherosclerosis_167_311 |
| ESTHER : Skoglund-Andersson_2003_Atherosclerosis_167_311 |
| PubMedSearch : Skoglund-Andersson_2003_Atherosclerosis_167_311 |
| PubMedID: 12818414 |
| Title : Polymorphism of HL +1075C, but not -480T, is associated with plasma high density lipoprotein cholesterol and apolipoprotein AI in men of a Chinese population - Fang_2002_Atherosclerosis_161_417 |
| Author(s) : Fang DZ , Liu BW |
| Ref : Atherosclerosis , 161 :417 , 2002 |
| Abstract : Fang_2002_Atherosclerosis_161_417 |
| ESTHER : Fang_2002_Atherosclerosis_161_417 |
| PubMedSearch : Fang_2002_Atherosclerosis_161_417 |
| PubMedID: 11888526 |
| Title : A common promoter polymorphism in the hepatic lipase gene (LIPC-480C>T) is associated with an increase in coronary calcification in type 1 diabetes - Hokanson_2002_Diabetes_51_1208 |
| Author(s) : Hokanson JE , Cheng S , Snell-Bergeon JK , Fijal BA , Grow MA , Hung C , Erlich HA , Ehrlich J , Eckel RH , Rewers M |
| Ref : Diabetes , 51 :1208 , 2002 |
| Abstract : Hokanson_2002_Diabetes_51_1208 |
| ESTHER : Hokanson_2002_Diabetes_51_1208 |
| PubMedSearch : Hokanson_2002_Diabetes_51_1208 |
| PubMedID: 11916946 |
| Title : Hepatic lipase gene variation is related to coronary reactivity in healthy young men - Fan_2001_Eur.J.Clin.Invest_31_574 |
| Author(s) : Fan Y , Laaksonen R , Janatuinen T , Vesalainen R , Nuutila P , Koivula T , Knuuti J , Lehtimaki T |
| Ref : European Journal of Clinical Investigation , 31 :574 , 2001 |
| Abstract : Fan_2001_Eur.J.Clin.Invest_31_574 |
| ESTHER : Fan_2001_Eur.J.Clin.Invest_31_574 |
| PubMedSearch : Fan_2001_Eur.J.Clin.Invest_31_574 |
| PubMedID: 11454011 |
| Title : Hepatic lipase promoter activity is reduced by the C-480T and G-216A substitutions present in the common LIPC gene variant, and is increased by Upstream Stimulatory Factor - Botma_2001_Atherosclerosis_154_625 |
| Author(s) : Botma GJ , Verhoeven AJ , Jansen H |
| Ref : Atherosclerosis , 154 :625 , 2001 |
| Abstract : Botma_2001_Atherosclerosis_154_625 |
| ESTHER : Botma_2001_Atherosclerosis_154_625 |
| PubMedSearch : Botma_2001_Atherosclerosis_154_625 |
| PubMedID: 11257263 |
| Title : Polymorphisms in the lipoprotein lipase and hepatic lipase genes and plasma lipid values in the Czech population - Hubacek_2001_Physiol.Res_50_345 |
| Author(s) : Hubacek JA , Waterworth DM , Pitha J , Humphries SE , Talmud PJ , Poledne R |
| Ref : Physiol Res , 50 :345 , 2001 |
| Abstract : Hubacek_2001_Physiol.Res_50_345 |
| ESTHER : Hubacek_2001_Physiol.Res_50_345 |
| PubMedSearch : Hubacek_2001_Physiol.Res_50_345 |
| PubMedID: 11551139 |
| Title : The T allele of the hepatic lipase promoter variant C-480T is associated with increased fasting lipids and HDL and increased preprandial and postprandial LpCIII:B : European Atherosclerosis Research Study (EARS) II - Jansen_1999_Arterioscler.Thromb.Vasc.Biol_19_303 |
| Author(s) : Jansen H , Chu G , Ehnholm C , Dallongeville J , Nicaud V , Talmud PJ |
| Ref : Arterioscler Thromb Vasc Biol , 19 :303 , 1999 |
| Abstract : Jansen_1999_Arterioscler.Thromb.Vasc.Biol_19_303 |
| ESTHER : Jansen_1999_Arterioscler.Thromb.Vasc.Biol_19_303 |
| PubMedSearch : Jansen_1999_Arterioscler.Thromb.Vasc.Biol_19_303 |
| PubMedID: 9974411 |
| Title : Absence of association between genetic variation in the LIPC gene promoter and plasma lipoproteins in three Canadian populations - Hegele_1999_Atherosclerosis_146_153 |
| Author(s) : Hegele RA , Harris SB , Brunt JH , Young TK , Hanley AJ , Zinman B , Connelly PW |
| Ref : Atherosclerosis , 146 :153 , 1999 |
| Abstract : Hegele_1999_Atherosclerosis_146_153 |
| ESTHER : Hegele_1999_Atherosclerosis_146_153 |
| PubMedSearch : Hegele_1999_Atherosclerosis_146_153 |
| PubMedID: 10487498 |
| Title : Common C-to-T substitution at position -480 of the hepatic lipase promoter associated with a lowered lipase activity in coronary artery disease patients - Jansen_1997_Arterioscler.Thromb.Vasc.Biol_17_2837 |
| Author(s) : Jansen H , Verhoeven AJ , Weeks L , Kastelein JJ , Halley DJ , van den Ouweland A , Jukema JW , Seidell JC , Birkenhager JC |
| Ref : Arterioscler Thromb Vasc Biol , 17 :2837 , 1997 |
| Abstract : Jansen_1997_Arterioscler.Thromb.Vasc.Biol_17_2837 |
| ESTHER : Jansen_1997_Arterioscler.Thromb.Vasc.Biol_17_2837 |
| PubMedSearch : Jansen_1997_Arterioscler.Thromb.Vasc.Biol_17_2837 |
| PubMedID: 9409263 |