Gene Locus : human-LIPC
Mode of mutation : Natural mutant
Disease : Hepatic triglyceride lipase Deficiency
Summary :
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification :
Torpedo_number : No torpedo number
Kinetic Parameter : No kinetic parameter
News : No news
Comment : The G-->A(-250) allele is associated with lower HL -250G\/A
| Title : The -250G\/A and -514C\/T Polymorphisms in Hepatic Lipase Gene Promoter Confers an Increased Risk of Hepatocellular Carcinoma in a Chinese Population - Niu_2018_Ann.Hepatol_17_992 |
| Author(s) : Niu CZ , Zhang FH , Li Y , Liu JJ , Bao CX |
| Ref : Ann Hepatol , 17 :992 , 2018 |
| Abstract : Niu_2018_Ann.Hepatol_17_992 |
| ESTHER : Niu_2018_Ann.Hepatol_17_992 |
| PubMedSearch : Niu_2018_Ann.Hepatol_17_992 |
| PubMedID: 30600300 |
| Gene_locus related to this paper: human-LIPC |
| Title : [Association of the hepatic lipase gene -250G\/A promoter polymorphism with the susceptibility to type 2 diabetes mellitus combining with coronary heart disease] - Wei_2009_Zhonghua.Yi.Xue.Yi.Chuan.Xue.Za.Zhi_26_219 |
| Author(s) : Wei M , Lu YS , Li PP |
| Ref : Zhonghua Yi Xue Yi Chuan Xue Za Zhi , 26 :219 , 2009 |
| Abstract : Wei_2009_Zhonghua.Yi.Xue.Yi.Chuan.Xue.Za.Zhi_26_219 |
| ESTHER : Wei_2009_Zhonghua.Yi.Xue.Yi.Chuan.Xue.Za.Zhi_26_219 |
| PubMedSearch : Wei_2009_Zhonghua.Yi.Xue.Yi.Chuan.Xue.Za.Zhi_26_219 |
| PubMedID: 19350521 |
| Gene_locus related to this paper: human-LIPC |
| Title : Association of the -250G\/A promoter polymorphism of the hepatic lipase gene with the risk of peripheral arterial disease in type 2 diabetic patients - Valdivielso_2008_J.Diabetes.Complications_22_273 |
| Author(s) : Valdivielso P , Ariza MJ , de la Vega-Roman C , Gonzalez-Alegre T , Rioja J , Ulzurrun E , Gonzalez-Santos P |
| Ref : J Diabetes Complications , 22 :273 , 2008 |
| Abstract : Valdivielso_2008_J.Diabetes.Complications_22_273 |
| ESTHER : Valdivielso_2008_J.Diabetes.Complications_22_273 |
| PubMedSearch : Valdivielso_2008_J.Diabetes.Complications_22_273 |
| PubMedID: 18413186 |
| Gene_locus related to this paper: human-LIPC |
| Title : The -250G\/A polymorphism in the hepatic lipase gene promoter influences the postprandial lipemic response in healthy men - Jimenez-Gomez_2008_Nutr.Metab.Cardiovasc.Dis_18_173 |
| Author(s) : Jimenez-Gomez Y , Perez-Jimenez F , Marin C , Gomez P , Moreno R , Delgado J , Perez-Martinez P , Gomez MJ , Lopez-Miranda J |
| Ref : Nutr Metab Cardiovasc Dis , 18 :173 , 2008 |
| Abstract : Jimenez-Gomez_2008_Nutr.Metab.Cardiovasc.Dis_18_173 |
| ESTHER : Jimenez-Gomez_2008_Nutr.Metab.Cardiovasc.Dis_18_173 |
| PubMedSearch : Jimenez-Gomez_2008_Nutr.Metab.Cardiovasc.Dis_18_173 |
| PubMedID: 17399967 |
| Gene_locus related to this paper: human-LIPC |
| Title : Hepatic lipase polymorphism and increased risk of peripheral arterial disease - Eller_2005_J.Intern.Med_258_344 |
| Author(s) : Eller P , Schgoer W , Mueller T , Tancevski I , Wehinger A , Ulmer H , Foeger B , Haltmayer M , Ritsch A , Patsch JR |
| Ref : J Intern Med , 258 :344 , 2005 |
| Abstract : Eller_2005_J.Intern.Med_258_344 |
| ESTHER : Eller_2005_J.Intern.Med_258_344 |
| PubMedSearch : Eller_2005_J.Intern.Med_258_344 |
| PubMedID: 16164573 |
| Title : The G-250A substitution in the promoter region of the hepatic lipase gene is associated with the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial - Zacharova_2005_J.Intern.Med_257_185 |
| Author(s) : Zacharova J , Todorova BR , Chiasson JL , Laakso M |
| Ref : J Intern Med , 257 :185 , 2005 |
| Abstract : Zacharova_2005_J.Intern.Med_257_185 |
| ESTHER : Zacharova_2005_J.Intern.Med_257_185 |
| PubMedSearch : Zacharova_2005_J.Intern.Med_257_185 |
| PubMedID: 15656877 |
| Title : Association between -250G\/A polymorphism of the hepatic lipase gene promoter and coronary artery disease and HDL-C levels in a Southern Brazilian population - de Andrade_2004_Clin.Genet_65_390 |
| Author(s) : de Andrade FM , Silveira FR , Arsand M , Antunes AL , Torres MR , Zago AJ , Callegari-Jaques SM , Hutz MH |
| Ref : Clin Genet , 65 :390 , 2004 |
| Abstract : de Andrade_2004_Clin.Genet_65_390 |
| ESTHER : de Andrade_2004_Clin.Genet_65_390 |
| PubMedSearch : de Andrade_2004_Clin.Genet_65_390 |
| PubMedID: 15099346 |
| Gene_locus related to this paper: human-LIPC |
| Title : The G-250A promoter polymorphism of the hepatic lipase gene predicts the conversion from impaired glucose tolerance to type 2 diabetes mellitus: the Finnish Diabetes Prevention Study - Todorova_2004_J.Clin.Endocrinol.Metab_89_2019 |
| Author(s) : Todorova B , Kubaszek A , Pihlajamaki J , Lindstrom J , Eriksson J , Valle TT , Hamalainen H , Ilanne-Parikka P , Keinanen-Kiukaanniemi S , Tuomilehto J , Uusitupa M , Laakso M |
| Ref : J Clinical Endocrinology Metab , 89 :2019 , 2004 |
| Abstract : Todorova_2004_J.Clin.Endocrinol.Metab_89_2019 |
| ESTHER : Todorova_2004_J.Clin.Endocrinol.Metab_89_2019 |
| PubMedSearch : Todorova_2004_J.Clin.Endocrinol.Metab_89_2019 |
| PubMedID: 15126514 |
| Title : G-250A substitution in promoter of hepatic lipase gene is associated with dyslipidemia and insulin resistance in healthy control subjects and in members of families with familial combined hyperlipidemia - Pihlajamaki_2000_Arterioscler.Thromb.Vasc.Biol_20_1789 |
| Author(s) : Pihlajamaki J , Karjalainen L , Karhapaa P , Vauhkonen I , Taskinen MR , Deeb SS , Laakso M |
| Ref : Arterioscler Thromb Vasc Biol , 20 :1789 , 2000 |
| Abstract : Pihlajamaki_2000_Arterioscler.Thromb.Vasc.Biol_20_1789 |
| ESTHER : Pihlajamaki_2000_Arterioscler.Thromb.Vasc.Biol_20_1789 |
| PubMedSearch : Pihlajamaki_2000_Arterioscler.Thromb.Vasc.Biol_20_1789 |
| PubMedID: 10894818 |
| Title : A hepatic lipase gene promoter polymorphism attenuates the increase in hepatic lipase activity with increasing intra-abdominal fat in women - Carr_1999_Arterioscler.Thromb.Vasc.Biol_19_2701 |
| Author(s) : Carr MC , Hokanson JE , Deeb SS , Purnell JQ , Mitchell ES , Brunzell JD |
| Ref : Arterioscler Thromb Vasc Biol , 19 :2701 , 1999 |
| Abstract : Carr_1999_Arterioscler.Thromb.Vasc.Biol_19_2701 |
| ESTHER : Carr_1999_Arterioscler.Thromb.Vasc.Biol_19_2701 |
| PubMedSearch : Carr_1999_Arterioscler.Thromb.Vasc.Biol_19_2701 |
| PubMedID: 10559014 |
| Title : Common variants in the promoter of the hepatic lipase gene are associated with lower levels of hepatic lipase activity, buoyant LDL, and higher HDL2 cholesterol - Zambon_1998_Arterioscler.Thromb.Vasc.Biol_18_1723 |
| Author(s) : Zambon A , Deeb SS , Hokanson JE , Brown BG , Brunzell JD |
| Ref : Arterioscler Thromb Vasc Biol , 18 :1723 , 1998 |
| Abstract : Zambon_1998_Arterioscler.Thromb.Vasc.Biol_18_1723 |
| ESTHER : Zambon_1998_Arterioscler.Thromb.Vasc.Biol_18_1723 |
| PubMedSearch : Zambon_1998_Arterioscler.Thromb.Vasc.Biol_18_1723 |
| PubMedID: 9812910 |