isoquinolinederivative18
General
Type : Piperazine,Isoindole,Indole
Chemical_Nomenclature : 2-amino-4-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-1-(1,3-dihydroisoindol-2-yl)butane-1,4-dione
Canonical SMILES : C1CN(CCN1C(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)C(=O)CC(C(=O)N4CC5=CC=CC=C5C4)N
InChI : InChI=1S\/C29H30F2N4O2\/c30-24-9-5-20(6-10-24)28(21-7-11-25(31)12-8-21)34-15-13-33(14-16-34)27(36)17-26(32)29(37)35-18-22-3-1-2-4-23(22)19-35\/h1-12,26,28H,13-19,32H2
InChIKey : ZKIQFLSGMMYCGS-UHFFFAOYSA-N
Other name(s) : isoquinoline derivative 18,CHEMBL367368,GTPL6536,SCHEMBL2367813,BDBM12195,Compound 18 [PMID: 15664838]
MW : 504.57
Formula : C29H30F2N4O2
CAS_number :
PubChem : 11375559
UniChem : ZKIQFLSGMMYCGS-UHFFFAOYSA-N
IUPHAR : 6536
Wikipedia :
Target
Families : isoquinolinederivative18 ligand of proteins in family: DPP4N_Peptidase_S9
Stucture :
Protein : human-DPP8
References (1)
| Title : Novel isoindoline compounds for potent and selective inhibition of prolyl dipeptidase DPP8 - Jiaang_2005_Bioorg.Med.Chem.Lett_15_687 |
| Author(s) : Jiaang WT , Chen YS , Hsu T , Wu SH , Chien CH , Chang CN , Chang SP , Lee SJ , Chen X |
| Ref : Bioorganic & Medicinal Chemistry Lett , 15 :687 , 2005 |
| Abstract : Jiaang_2005_Bioorg.Med.Chem.Lett_15_687 |
| ESTHER : Jiaang_2005_Bioorg.Med.Chem.Lett_15_687 |
| PubMedSearch : Jiaang_2005_Bioorg.Med.Chem.Lett_15_687 |
| PubMedID: 15664838 |
| Gene_locus related to this paper: human-DPP8 |