Inhibitor Report for: diEt-PFP General
Type Organophosphate Chemical_Nomenclature diethyl 1,1,1,3,3,3-hexafluoropropan-2-yl phosphate Canonical SMILES CCOP(=O)(OCC)OC(C(F)(F)F)C(F)(F)F InChI InChI=1S/C7H11F6O4P/c1-3-15-18(14,16-4-2)17-5(6(8,9)10)7(11,12)13/h5H,3-4H2,1-2H3 InChIKey YEMNWQQLKIIPRQ-UHFFFAOYSA-N Other name(s) ZINC05718302 ; Phosphoric acid diethyl=1-(trifluoromethyl)-2,2,2-trifluoroethyl ester ; 2-diethoxyphosphoryloxy-1,1,1,3,3,3-hexafluoro-propane
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Target
Families | diEt-PFP ligand of proteins in family: ACHE , BCHE
References:
Search PubMed for references concerning:
diEt-PFP
Title: Synthesis of organophosphates with fluorine-containing leaving groups as serine esterase inhibitors with potential for Alzheimer disease therapeuticsMakhaeva GF , Aksinenko AY , Sokolov VB , Serebryakova OG , Richardson RJ Ref: Bioorganic & Medicinal Chemistry Lett, 19 :5528, 2009 : PubMed Abstract ESTHER: Makhaeva_2009_Bioorg.Med.Chem.Lett_19_5528 PubMedSearch: Makhaeva 2009 Bioorg.Med.Chem.Lett 19 5528 PubMedID: 19717305 Inhibitor(s) related to this paper: diBu-PFP ,
diEt-PFP Abstract
Acetylcholinesterase and butyrylcholinesterase inhibitors are potential cognition enhancers in Alzheimer disease. O,O-Dialkylphosphate inhibitors with 1-substituted 2,2,2-trifluoroethoxy leaving groups were synthesized by phosphonate-phosphate rearrangement. Substituents in the 1-position of the leaving group along with the O-alkyl groups modulated potency and selectivity against acetylcholinesterase, butyrylcholinesterase, and carboxylesterase.
Title: Esterase profile and analysis of structure-inhibitor selectivity relationships for homologous phosphorylated 1-hydroperfluoroisopropanolsMakhaeva GF , Serebryakova OG , Boltneva NP , Galenko TG , Aksinenko AY , Sokolov VB , Martynov IV Ref: Dokl Biochem Biophys, 423 :352, 2008 : PubMed Abstract
