Monoacylglycerol lipase (human-MGLL) inhibitor close to ZYH (cyclohexyl replaced by Fluorophenyl) IC50 4.6 nM
Type : Azetidin,Piperazine,Carboxamide,Pyrimidine,PET probe,Indole
Chemical_Nomenclature : 4-[1-[1-(4-fluorophenyl)indole-5-carbonyl]azetidin-3-yl]-1-pyrimidin-2-ylpiperazin
Canonical SMILES : O=C(C3=CC2=C([N](C1=CC=C(F)C=C1)C=C2)C=C3)N6CC(N5CCN(C4=NC=CC=N4)CC5)C6
InChI : InChI=1S\/C26H25FN6O\/c27-21-3-5-22(6-4-21)33-11-8-19-16-20(2-7-24(19)33)25(34)32-17-23(18-32)30-12-14-31(15-13-30)26-28-9-1-10-29-26\/h1-11,16,23H,12-15,17-18H2
InChIKey : RLHONBOIUHNTIZ-UHFFFAOYSA-N
Other name(s) : 4-(1-{[1-(4-Fluorophenyl)-1H-indol-5-yl]carbonyl}azetidin-3-yl)-1-pyrimidin-2-ylpiperazin
MW : 456.52
Formula : C26H25FN6O
CAS_number :
PubChem : 66823546
UniChem : RLHONBOIUHNTIZ-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Families : ZYH-deriv-F ligand of proteins in family: Monoglyceridelipase_lysophospholip
Stucture :
Protein : human-MGLL
Title : Novel Reversible-Binding PET Ligands for Imaging Monoacylglycerol Lipase Based on the Piperazinyl Azetidine Scaffold - Rong_2021_J.Med.Chem__ |
Author(s) : Rong J , Mori W , Xia X , Schafroth MA , Zhao C , Van RS , Yamasaki T , Chen J , Xiao Z , Haider A , Ogasawara D , Hiraishi A , Shao T , Zhang Y , Chen Z , Pang F , Hu K , Xie L , Fujinaga M , Kumata K , Gou Y , Fang Y , Gu S , Wei H , Bao L , Xu H , Collier TL , Shao Y , Carson RE , Cravatt BF , Wang L , Zhang MR , Liang SH |
Ref : Journal of Medicinal Chemistry , : , 2021 |
Abstract : Rong_2021_J.Med.Chem__ |
ESTHER : Rong_2021_J.Med.Chem__ |
PubMedSearch : Rong_2021_J.Med.Chem__ |
PubMedID: 34569803 |
Gene_locus related to this paper: human-MGLL |