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ZT-1

precusor of huperzineA rapidly hydrolised

General

Type : Derivative of Huperzine

Chemical_Nomenclature : (5R,9R)-5-(r-chloro-2-hydroxy-3-methoxybenzylidene-amino)-11-ethlidene-7-methyl-1,2,5,6,9,10-hexahydro-5,9-methanocycloocta[b]pyridin-2-one

Canonical SMILES : CC=C1C2CC3=C(C1(CC(=C2)C)NC=C4C=C(C=C(C4=O)OC)Cl)C=CC(=O)N3

InChI : InChI=1S\/C23H23ClN2O3\/c1-4-17-14-7-13(2)11-23(17,18-5-6-21(27)26-19(18)9-14)25-12-15-8-16(24)10-20(29-3)22(15)28\/h4-8,10,12,14,25H,9,11H2,1-3H3,(H,26,27)\/b15-12-,17-4+

InChIKey : GYTJFKCCTYZWGL-WQOXWKGMSA-N

Other name(s) : ZT1,Mimopezil,UNII-4MU6P880QL,Xipulin,Mimopezil [INN]

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MW : 426.94

Formula : C24H27ClN2O3

CAS_number :

PubChem : 44153604

UniChem : GYTJFKCCTYZWGL-WQOXWKGMSA-N

Target

Families : ZT-1 ligand of proteins in family
ACHE BCHE

References (2)

1. Simultaneous determination of ZT-1 and its metabolite Huperzine A in plasma by high-performance liquid chromatography with ultraviolet detection

Title : Simultaneous determination of ZT-1 and its metabolite Huperzine A in plasma by high-performance liquid chromatography with ultraviolet detection - Wei_2006_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_830_120

Author(s) : Wei G , Xiao S , Lu R , Liu C

Ref : Journal of Chromatography B Analyt Technol Biomed Life Sciences , 830 :120 , 2006

Abstract : Wei_2006_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_830_120

ESTHER : Wei_2006_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_830_120

PubMedSearch : Wei_2006_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_830_120

PubMedID: 16288904

2. A sensitive method for the determination of the novel cholinesterase inhibitor ZT-1 and its active metabolite huperzine A in rat blood using liquid chromatography\/tandem mass spectrometry

Title : A sensitive method for the determination of the novel cholinesterase inhibitor ZT-1 and its active metabolite huperzine A in rat blood using liquid chromatography\/tandem mass spectrometry - Li_2004_Rapid.Commun.Mass.Spectrom_18_651

Author(s) : Li C , Du F , Yu C , Xu X , Zheng J , Xu F , Zhu D

Ref : Rapid Commun Mass Spectrom , 18 :651 , 2004

Abstract : Li_2004_Rapid.Commun.Mass.Spectrom_18_651

ESTHER : Li_2004_Rapid.Commun.Mass.Spectrom_18_651

PubMedSearch : Li_2004_Rapid.Commun.Mass.Spectrom_18_651

PubMedID: 15052575

Array
(
    [id] => 4467
    [inhibitor] => ZT-1
    [type] => Array
        (
            [0] => Derivative of Huperzine
        )

    [other_name] => Array
        (
            [0] => ZT1
            [1] => Mimopezil
            [2] => UNII-4MU6P880QL
            [3] => Xipulin
            [4] => Mimopezil [INN]
        )

    [chemical_nomenclature] => (5R,9R)-5-(r-chloro-2-hydroxy-3-methoxybenzylidene-amino)-11-ethlidene-7-methyl-1,2,5,6,9,10-hexahydro-5,9-methanocycloocta[b]pyridin-2-one
    [formula] => C24H27ClN2O3
    [cas_number] => 
    [mw] => 426.94
    [pick_me_to_call] => display_script
    [kinetic_parameter] => 
    [paper] => Li_2004_Rapid.Commun.Mass.Spectrom_18_651 || Wei_2006_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_830_120
    [comment] => precusor of huperzineA rapidly hydrolised
    [gene_locus] => 
    [kin_inhibitor] => 
    [cid] => 44153604
    [family] => ACHE || BCHE
    [inchikey] => GYTJFKCCTYZWGL-WQOXWKGMSA-N
    [canonicalsmiles] => CC=C1C2CC3=C(C1(CC(=C2)C)NC=C4C=C(C=C(C4=O)OC)Cl)C=CC(=O)N3
    [inchi] => InChI=1S\/C23H23ClN2O3\/c1-4-17-14-7-13(2)11-23(17,18-5-6-21(27)26-19(18)9-14)25-12-15-8-16(24)10-20(29-3)22(15)28\/h4-8,10,12,14,25H,9,11H2,1-3H3,(H,26,27)\/b15-12-,17-4+
    [wikipedia] => 
    [iupharlig] => 
    [structure] => 
    [substrate] => 
    [interact_gene_locus] => 
    [mutation] => 
    [comment2] => 
    [extoxnet] => 
    [news] => 
    [theoretical_model] => 
)