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Inhibitor Report for: ZLWH-23

anti-AChE potency (IC50 = 0.27 microM) and selective BuChE inhibition (IC50 = 20.82 microM), as well as moderate GSK-3 inhibition (IC50 = 6.78 microM)


General
Type Piperidine, GSK-3 kinase inhibitor, Carboxamide, Multitarget, Indole, Cyclopropyl, beta-carboline
Chemical_Nomenclature 1-(cyclopropanecarbonylamino)-N-[2-[1-[(2-fluorophenyl)methyl]piperidin-4-yl]ethyl]-9H-pyrido[3,4-b]indole-7-carboxamide
Canonical SMILES C1CC1C(=O)NC2=NC=CC3=C2NC4=C3C=CC(=C4)C(=O)NCCC5CCN(CC5)CC6=CC=CC=C6F
InChI InChI=1S/C30H32FN5O2/c31-25-4-2-1-3-22(25)18-36-15-11-19(12-16-36)9-13-33-29(37)21-7-8-23-24-10-14-32-28(27(24)34-26(23)17-21)35-30(38)20-5-6-20/h1-4,7-8,10,14,17,19-20,34H,5-6,9,11-13,15-16,18H2,(H,33,37)(H,32,35,38)
InChIKey AMLAWNFGPZNOOW-UHFFFAOYSA-N
Other name(s) HY-144316 ; CS-0379471
________________________________________________________________________________________________
MW|513.6
Formula|C30H32FN5O2
CAS_number|
PubChem|163322222
UniChem|AMLAWNFGPZNOOW-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | ZLWH-23 ligand of proteins in family: ACHE

References:
Search PubMed for references concerning: ZLWH-23
    Title: Discovery of novel beta-carboline derivatives as selective AChE inhibitors with GSK-3beta inhibitory property for the treatment of Alzheimer's disease
    Liu W, Liu X, Gao Y, Wu L, Huang Y, Chen H, Li D, Zhou L, Wang N and Zhao Q <2 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 229:114095, 2021 : PubMed