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Inhibitor Report for: ZK8

covalent inhibitor used to transform an esterase into an enantioselective catecholase through bioconjugation of this versatile metal-chelating inhibitor


General
Type Organophosphate, Pyridine, Metal ion chelator
Chemical_Nomenclature hexyl-[2-(3-oxidanylpyridin-2-yl)pyridin-3-yl]oxy-phosphinic acid
Canonical SMILES CCCCCCP(=O)(O)OC1=C(N=CC=C1)C2=C(C=CC=N2)O
InChI InChI=1S/C16H21N2O4P/c1-2-3-4-5-12-23(20,21)22-14-9-7-11-18-16(14)15-13(19)8-6-10-17-15/h6-11,19H,2-5,12H2,1H3,(H,20,21)
InChIKey QYCWYIQRYAMGGW-UHFFFAOYSA-N
Other name(s)
________________________________________________________________________________________________
MW|336.32
Formula|C16H21N2O4P
CAS_number|
PubChem|168355673
UniChem|QYCWYIQRYAMGGW-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | ZK8 ligand of proteins in family: Hormone-sensitive_lipase_like
Stucture | 2 structures: 8PC7, 6RKY
Protein | 9zzzz-a0a2k8jn75

References:
Search PubMed for references concerning: ZK8
    Title: Transforming an esterase into an enantioselective catecholase through bioconjugation of a versatile metal-chelating inhibitor
    Fernandez-Lopez L, Cea-Rama I, Alvarez-Malmagro J, Ressmann AK, Gonzalez-Alfonso JL, Coscolin C, Shahgaldian P, Plou FJ, Modregger J and Ferrer M <2 more author(s)>
    Ref: Chem Commun (Camb), :, 2023 : PubMed