Z-Pro-Prolinal-IC3
General
Type : Benzyloxycarbonyl,Pyrrolidine,Peptide,Cyanide
Chemical_Nomenclature : (2S)-1-[(2S)-1-(4-phenylbutanoyl)pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
Canonical SMILES : C1CC(N(C1)C(=O)C2CCCN2C(=O)CCCC3=CC=CC=C3)C#N
InChI : InChI=1S\/C20H25N3O2\/c21-15-17-10-5-13-22(17)20(25)18-11-6-14-23(18)19(24)12-4-9-16-7-2-1-3-8-16\/h1-3,7-8,17-18H,4-6,9-14H2\/t17-,18-\/m0\/s1
InChIKey : SPXFAUXQZWJGCJ-ROUUACIJSA-N
Other name(s) : IC3,2P6,CHEMBL189620,4an0,KYP-2047,BDBM50155838,ZINC13584669,KYP-2047, >=95\% (HPLC)
MW : 339.43
Formula : C20H25N3O2
CAS_number :
PubChem : 11198569
UniChem : SPXFAUXQZWJGCJ-ROUUACIJSA-N
IUPHAR :
Wikipedia :
Target
Families : Z-Pro-Prolinal-IC3 ligand of proteins in family: S9N_PPCE_Peptidase_S9
Stucture : 4AN0 Prolyl Oligopeptidase from porcine brain with a covalently bound inhibitor IC-3
Protein : pig-ppce
References (2)
| Title : A prolyl oligopeptidase inhibitor, KYP-2047, reduces alpha-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease - Myohanen_2012_Br.J.Pharmacol_166_1097 |
| Author(s) : Myohanen TT , Hannula MJ , Van Elzen R , Gerard M , Van der Veken P , Garcia-Horsman JA , Baekelandt V , Mannisto PT , Lambeir AM |
| Ref : British Journal of Pharmacology , 166 :1097 , 2012 |
| Abstract : Myohanen_2012_Br.J.Pharmacol_166_1097 |
| ESTHER : Myohanen_2012_Br.J.Pharmacol_166_1097 |
| PubMedSearch : Myohanen_2012_Br.J.Pharmacol_166_1097 |
| PubMedID: 22233220 |
| Title : Molecular dynamics, crystallography and mutagenesis studies on the substrate gating mechanism of prolyl oligopeptidase. - Kaszuba_2012_Biochimie_94_1398 |
| Author(s) : Kaszuba K , Rog T , Danne R , Canning P , Fulop V , Juhasz T , Szeltner Z , St Pierre JF , Garcia-Horsman A , Mannisto PT , Karttunen M , Hokkanen J , Bunker A |
| Ref : Biochimie , 94 :1398 , 2012 |
| Abstract : Kaszuba_2012_Biochimie_94_1398 |
| ESTHER : Kaszuba_2012_Biochimie_94_1398 |
| PubMedSearch : Kaszuba_2012_Biochimie_94_1398 |
| PubMedID: 22484394 |
| Gene_locus related to this paper: pig-ppce |