Type : Pyrrolidine,Gliptin,Adamantyl,Azabicyclo
Chemical_Nomenclature : (2S)-2-amino-1-[(1S,3S,5S)-3-(aminomethyl)-2-azabicyclo[3.1.0]hexan-2-yl]-2-[(3R,5S)-3,5-dihydroxy-1-adamantyl]ethanone
Canonical SMILES : C1C2CC2N(C1CN)C(=O)C(C34CC5CC(C3)(CC(C5)(C4)O)O)N
InChI : InChI=1S\/C18H29N3O3\/c19-6-12-1-11-2-13(11)21(12)15(22)14(20)16-3-10-4-17(23,7-16)9-18(24,5-10)8-16\/h10-14,23-24H,1-9,19-20H2\/t10?,11-,12+,13+,14-,16?,17-,18+\/m1\/s1
InChIKey : NFCLGRKAEZJOPE-ZRDSGBHLSA-N
Other name(s) : C8S
MW : 335.4
Formula : C18H29N3O3
CAS_number :
PubChem : 137349065
UniChem : NFCLGRKAEZJOPE-ZRDSGBHLSA-N
IUPHAR :
Wikipedia :
Families : VildaSaxagliptin-analogue ligand of proteins in family: DPP4N_Peptidase_S9
Stucture : 6B1O The structure of DPP4 in complex with Vildagliptin Analog
Protein : human-DPP4
Title : A comparative study of the binding properties, dipeptidyl peptidase-4 (DPP-4) inhibitory activity and glucose-lowering efficacy of the DPP-4 inhibitors alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin in mice - Berger_2018_Endocrinol.Diabetes.Metab_1_e00002 |
Author(s) : Berger JP , SinhaRoy R , Pocai A , Kelly TM , Scapin G , Gao YD , Pryor KAD , Wu JK , Eiermann GJ , Xu SS , Zhang X , Tatosian DA , Weber AE , Thornberry NA , Carr RD |
Ref : Endocrinol Diabetes Metab , 1 :e00002 , 2018 |
Abstract : Berger_2018_Endocrinol.Diabetes.Metab_1_e00002 |
ESTHER : Berger_2018_Endocrinol.Diabetes.Metab_1_e00002 |
PubMedSearch : Berger_2018_Endocrinol.Diabetes.Metab_1_e00002 |
PubMedID: 30815539 |
Gene_locus related to this paper: human-DPP4 |