UCI-80224067
Compound 8o inhibits human and mouse PrCP at IC50 values of 1 and 2 nM and is not active (IC50 > 25 M) against a panel of closely related proteases
General
Type : Pyrrolidine,Imidazole,Benzimidazole
Chemical_Nomenclature : 2-amino-N-[1-[2-(5,6-dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]-1-oxo-3-(4-phenylphenyl)butan-2-yl]-2-methylpropanamide
Canonical SMILES : CC(C1=CC=C(C=C1)C2=CC=CC=C2)C(C(=O)N3CCCC3C4=NC5=CC(=C(C=C5N4)Cl)Cl)NC(=O)C(C)(C)N
InChI : InChI=1S\/C31H33Cl2N5O2\/c1-18(19-11-13-21(14-12-19)20-8-5-4-6-9-20)27(37-30(40)31(2,3)34)29(39)38-15-7-10-26(38)28-35-24-16-22(32)23(33)17-25(24)36-28\/h4-6,8-9,11-14,16-18,26-27H,7,10,15,34H2,1-3H3,(H,35,36)(H,37,40)
InChIKey : PHUWAMRFIHBBMJ-UHFFFAOYSA-N
Other name(s) : Compound 80
MW : 578.5
Formula : C31H33Cl2N5O2
CAS_number :
PubChem : 75292568
UniChem : PHUWAMRFIHBBMJ-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : UCI-80224067 ligand of proteins in family: Prolylcarboxypeptidase
Stucture :
Protein : human-PRCP
References (1)
| Title : Design and synthesis of prolylcarboxypeptidase (PrCP) inhibitors to validate PrCP as a potential target for obesity - Zhou_2010_J.Med.Chem_53_7251 |
| Author(s) : Zhou C , Garcia-Calvo M , Pinto S , Lombardo M , Feng Z , Bender K , Pryor KD , Bhatt UR , Chabin RM , Geissler WM , Shen Z , Tong X , Zhang Z , Wong KK , Roy RS , Chapman KT , Yang L , Xiong Y |
| Ref : Journal of Medicinal Chemistry , 53 :7251 , 2010 |
| Abstract : Zhou_2010_J.Med.Chem_53_7251 |
| ESTHER : Zhou_2010_J.Med.Chem_53_7251 |
| PubMedSearch : Zhou_2010_J.Med.Chem_53_7251 |
| PubMedID: 20857914 |
| Gene_locus related to this paper: human-PRCP |