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Triflupromazine

Dopaminergic antagonist, an antiemetic, a first generation antipsychotic and an anticoronaviral agent

General

Type : Phenothiazine,Sulfur Compound,Trifluoro,Not A\/B H target

Chemical_Nomenclature : N,N-dimethyl-3-[2-(trifluoromethyl)phenothiazin-10-yl]propan-1-amine

Canonical SMILES : CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)C(F)(F)F

InChI : InChI=1S\/C18H19F3N2S\/c1-22(2)10-5-11-23-14-6-3-4-7-16(14)24-17-9-8-13(12-15(17)23)18(19,20)21\/h3-4,6-9,12H,5,10-11H2,1-2H3

InChIKey : XSCGXQMFQXDFCW-UHFFFAOYSA-N

Other name(s) : triflupromazine,Fluopromazine,Trifluopromazine,Vesprin,Adazine,CHEBI:9711,CHEMBL570,SCHEMBL44085,ZINC538507

MW : 352.4

Formula : C18H19F3N2S

CAS_number : 146-54-3

PubChem : 5568

UniChem : XSCGXQMFQXDFCW-UHFFFAOYSA-N

Target

References (4)

Title : Inactivation of cholinesterase induced by chlorpromazine cation radicals - Muraoka_2003_Pharmacol.Toxicol_92_100
Author(s) : Muraoka S , Miura T
Ref : Pharmacol Toxicol , 92 :100 , 2003
Abstract : Muraoka_2003_Pharmacol.Toxicol_92_100
ESTHER : Muraoka_2003_Pharmacol.Toxicol_92_100
PubMedSearch : Muraoka_2003_Pharmacol.Toxicol_92_100
PubMedID: 12747580

Title : Inhibition of butyrylcholinesterase by phenothiazine derivatives - Debord_2002_J.Enzyme.Inhib.Med.Chem_17_197
Author(s) : Debord J , Merle L , Bollinger JC , Dantoine T
Ref : J Enzyme Inhib Med Chem , 17 :197 , 2002
Abstract : Debord_2002_J.Enzyme.Inhib.Med.Chem_17_197
ESTHER : Debord_2002_J.Enzyme.Inhib.Med.Chem_17_197
PubMedSearch : Debord_2002_J.Enzyme.Inhib.Med.Chem_17_197
PubMedID: 12443046

Title : Influence of dietary protein on the effect of coumaphos and triflupromazine interaction in sheep - Gopal_1976_Am.J.Vet.Res_37_1143
Author(s) : Gopal T , Oehme FW , Omer S
Ref : American Journal of Veterinary Research , 37 :1143 , 1976
Abstract : Gopal_1976_Am.J.Vet.Res_37_1143
ESTHER : Gopal_1976_Am.J.Vet.Res_37_1143
PubMedSearch : Gopal_1976_Am.J.Vet.Res_37_1143
PubMedID: 984539

Title : Central and peripheral actions of anticholinergic drugs when administered with triflupromazine -
Author(s) : Brimblecombe RW , Green DM , Aldous FA , Thompson PB
Ref : Neuropharmacology , 10 :93 , 1971
PubMedID: 5569310 
Array
(
    [id] => 5529
    [inhibitor] => Triflupromazine
    [type] => Array
        (
            [0] => Phenothiazine
            [1] => Sulfur Compound
            [2] => Trifluoro
            [3] => Not A\/B H target
        )

    [other_name] => Array
        (
            [0] => triflupromazine
            [1] => Fluopromazine
            [2] => Trifluopromazine
            [3] => Vesprin
            [4] => Adazine
            [5] => CHEBI:9711
            [6] => CHEMBL570
            [7] => SCHEMBL44085
            [8] => ZINC538507
        )

    [chemical_nomenclature] => N,N-dimethyl-3-[2-(trifluoromethyl)phenothiazin-10-yl]propan-1-amine
    [formula] => C18H19F3N2S
    [cas_number] => 146-54-3
    [mw] => 352.4
    [pick_me_to_call] => display_script
    [kinetic_parameter] => 
    [paper] => Brimblecombe_1971_Neuropharmacol_10_93 || Debord_2002_J.Enzyme.Inhib.Med.Chem_17_197 || Muraoka_2003_Pharmacol.Toxicol_92_100 || Gopal_1976_Am.J.Vet.Res_37_1143
    [comment] => Dopaminergic antagonist, an antiemetic, a first generation antipsychotic and an anticoronaviral agent
    [gene_locus] => 
    [kin_inhibitor] => 
    [cid] => 5568
    [family] => 
    [inchikey] => XSCGXQMFQXDFCW-UHFFFAOYSA-N
    [canonicalsmiles] => CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)C(F)(F)F
    [inchi] => InChI=1S\/C18H19F3N2S\/c1-22(2)10-5-11-23-14-6-3-4-7-16(14)24-17-9-8-13(12-15(17)23)18(19,20)21\/h3-4,6-9,12H,5,10-11H2,1-2H3
    [wikipedia] => 
    [iupharlig] => 
    [structure] => 
    [substrate] => 
    [interact_gene_locus] => 
    [mutation] => 
    [comment2] => 
    [extoxnet] => 
    [news] => 
    [theoretical_model] => 
)