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Inhibitor Report for: Trichloropropene-oxide

A potent epoxide hydrase and aryl hydrocarbon hydroxylase inhibitor. It enhances the tumor-initiating ability of certain carcinogens.


General
Type Epoxide
Chemical_Nomenclature 2-(trichloromethyl)oxirane
Canonical SMILES C1C(O1)C(Cl)(Cl)Cl
InChI InChI=1S/C3H3Cl3O/c4-3(5,6)2-1-7-2/h2H,1H2
InChIKey VFEXYZINKMLLAK-UHFFFAOYSA-N
Other name(s) 2-(Trichloromethyl)oxirane ; Trichloropropene oxide ; TCPO ; SCHEMBL2550267 ; 1,2-Epoxy-3,3,3-trichloropropane ; (Trichloromethyl)oxirane
________________________________________________________________________________________________
MW|161.41
Formula|C3H3Cl3O
CAS_number|3083-23-6
PubChem|18321
UniChem|VFEXYZINKMLLAK-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | Trichloropropene-oxide ligand of proteins in family: Epoxide_hydrolase
Protein | human-EPHX1

References:
Search PubMed for references concerning: Trichloropropene-oxide

9 more
    Title: Human liver cytosolic epoxide hydrolases
    Schladt L, Thomas H, Hartmann R, Oesch F
    Ref: European Journal of Biochemistry, 176:715, 1988 : PubMed

            

    Title: Inhibition of mono-oxygenase activities by 1,1,1-trichloropropene 2,3-oxide, an inhibitor of epoxide hydrase, in rat liver microsomes
    Shimada T, Sato R
    Ref: Biochemical Pharmacology, 28:1777, 1979 : PubMed

            

    Title: Effects of the epoxide hydrase inhibitor, 1,1,1-trichloropropane-2,3-oxide on the genetic activity of aflatoxin B1 metabolites in in vitro activation test systems
    Callen DF, Ong TM
    Ref: Mutat Res, 49:371, 1978 : PubMed