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Inhibitor Report for: Theophylline

Not A/B H target. Theophylline is a natural alkaloid dimethylxanthine derivative of xanthine isolated from the plants Camellia sinensis and Coffea arabica, green and black tea. Theophylline appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize adenosine. Physiologically, this agent relaxes bronchial smooth muscle, produces vasodilation (except in cerebral vessels), stimulates the CNS, stimulates cardiac muscle, induces diuresis, and increases gastric acid secretion; it may also suppress inflammation and improve contractility of the diaphragm. Theophylline played an important role in the management of both acute and chronic reversible airway obstruction, in particular asthma and chronic bronchitis. However, it has a narrow safety window, which, along with its variability in disposition, makes dosing difficult to predict and toxicity difficult to prevent. Symptoms of toxicity include tachycardia, severe restlessness, agitation, nausea and vomiting, particularly at high blood concentrations

Type Alkaloid, Natural, Not A/B H target
Chemical_Nomenclature 1,3-dimethyl-7H-purine-2,6-dione
Canonical SMILES CN1C2=C(C(=O)N(C1=O)C)NC=N2
InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9)
Other name(s) 1,3-Dimethylxanthine ; Theophyllin ; Elixophyllin ; CHEMBL190 ; CHEBI:28177 ; ZINC18043251 ; DB-053224

Families | Theophylline ligand of proteins in family: Pectinacetylesterase-Notum
Stucture | 1 structure: 6TUZ: Theophylline- human Notum complex
Protein | human-NOTUM

Search PubMed for references concerning: Theophylline

8 more
    Title: Low-dose theophylline does not exert its anti-inflammatory effects in mild asthma through upregulation of interleukin-10 in alveolar macrophages
    Oliver B, Tomita K, Keller A, Caramori G, Adcock I, Chung KF, Barnes PJ, Lim S
    Ref: Allergy, 56:1087, 2001 : PubMed


    Title: Concurrent administration of donepezil HCl and theophylline: assessment of pharmacokinetic changes following multiple-dose administration in healthy volunteers
    Tiseo PJ, Foley K, Friedhoff LT
    Ref: British Journal of Clinical Pharmacology, 46 Suppl 1:35, 1998 : PubMed


    Title: Theophylline compounds and myasthenia gravis. II. Clinical report of nine cases
    Brumlik J, Jacobs R, Karczmar AG
    Ref: Clinical Pharmacology & Therapeutics, 14:380, 1973 : PubMed