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Inhibitor Report for: Taurodeoxycholate

Activator of Bile salt activated lipase. Product of conjugation of cholic acid with taurine. Its sodium salt is the chief ingredient of the bile of carnivorous animals. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as a cholagogue and cholerectic. A bile salt formed in the liver by conjugation of deoxycholate with taurine, usually as the sodium salt. It is used as a cholagogue and choleretic, also industrially as a fat emulsifier.


General
Type Natural, Steroid, Detergent, Sulfur Compound, Surfactant
Chemical_Nomenclature 2-[[(4R)-4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]ethanesulfonic acid
Canonical SMILES CC(CCC(=O)NCCS(=O)(=O)O)C1CCC2C1(C(CC3C2CCC4C3(CCC(C4)O)C)O)C
InChI InChI=1S/C26H45NO6S/c1-16(4-9-24(30)27-12-13-34(31,32)33)20-7-8-21-19-6-5-17-14-18(28)10-11-25(17,2)22(19)15-23(29)26(20,21)3/h16-23,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17-,18-,19+,20-,21+,22+,23+,25+,26-/m1/s1
InChIKey AWDRATDZQPNJFN-VAYUFCLWSA-N
Other name(s) Taurodeoxycholic acid ; Deoxycholyltaurine ; Tudcabil ; Taurodesoxycholic acid ; TDOC ; CHEBI:9410 ; NaTDC ; CHEMBL412272
________________________________________________________________________________________________
MW|499.7
Formula|C26H45NO6S
CAS_number|516-50-7
PubChem|2733768
UniChem|AWDRATDZQPNJFN-VAYUFCLWSA-N
IUPHAR|
Wikipedia|

Target
Families | Taurodeoxycholate ligand of proteins in family: Pancreatic_lipase
Protein | human-PNLIPRP2, human-PNLIP

References:
Search PubMed for references concerning: Taurodeoxycholate

5 more
    Title: IR spectroscopy analysis of pancreatic lipase-related protein 2 interaction with phospholipids: 1. Discriminative recognition of mixed micelles versus liposomes
    Mateos-Diaz E, Bakala N'Goma JC, Byrne D, Robert S, Carriere F, Gaussier H
    Ref: Chemistry & Physic of Lipids, 211:52, 2018 : PubMed

            

    Title: Efficient heterologous expression of Fusarium solani lipase, FSL2, in Pichia pastoris, functional characterization of the recombinant enzyme and molecular modeling
    Jallouli R, Parsiegla G, Carriere F, Gargouri Y, Bezzine S
    Ref: Int J Biol Macromol, 94:61, 2016 : PubMed

            

    Title: A comparative study on two fungal lipases from Thermomyces lanuginosus and Yarrowia lipolytica shows the combined effects of detergents and pH on lipase adsorption and activity
    Aloulou A, Puccinelli D, de Caro A, Leblond Y, Carriere F
    Ref: Biochimica & Biophysica Acta, 1771:1446, 2007 : PubMed