Taurodeoxycholate
Activator of Bile salt activated lipase. Product of conjugation of cholic acid with taurine. Its sodium salt is the chief ingredient of the bile of carnivorous animals. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as a cholagogue and cholerectic. A bile salt formed in the liver by conjugation of deoxycholate with taurine, usually as the sodium salt. It is used as a cholagogue and choleretic, also industrially as a fat emulsifier.
General
Type : Natural,Steroid,Detergent,Sulfur Compound,Surfactant,Phenanthrene
Chemical_Nomenclature : 2-[[(4R)-4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]ethanesulfonic acid
Canonical SMILES : CC(CCC(=O)NCCS(=O)(=O)O)C1CCC2C1(C(CC3C2CCC4C3(CCC(C4)O)C)O)C
InChI : InChI=1S\/C26H45NO6S\/c1-16(4-9-24(30)27-12-13-34(31,32)33)20-7-8-21-19-6-5-17-14-18(28)10-11-25(17,2)22(19)15-23(29)26(20,21)3\/h16-23,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)\/t16-,17-,18-,19+,20-,21+,22+,23+,25+,26-\/m1\/s1
InChIKey : AWDRATDZQPNJFN-VAYUFCLWSA-N
Other name(s) : Taurodeoxycholic acid,Deoxycholyltaurine,Tudcabil,Taurodesoxycholic acid,TDOC,CHEBI:9410,NaTDC,CHEMBL412272
MW : 499.7
Formula : C26H45NO6S
CAS_number : 516-50-7
PubChem : 2733768
UniChem : AWDRATDZQPNJFN-VAYUFCLWSA-N
IUPHAR :
Wikipedia :
Target
Families : Taurodeoxycholate ligand of proteins in family: Pancreatic_lipase
Stucture :
Protein : human-PNLIPRP2 || human-PNLIP
References (8)
| Title : IR spectroscopy analysis of pancreatic lipase-related protein 2 interaction with phospholipids: 1. Discriminative recognition of mixed micelles versus liposomes - Mateos-Diaz_2018_Chem.Phys.Lipids_211_52 |
| Author(s) : Mateos-Diaz E , Bakala N'Goma JC , Byrne D , Robert S , Carriere F , Gaussier H |
| Ref : Chemistry & Physic of Lipids , 211 :52 , 2018 |
| Abstract : Mateos-Diaz_2018_Chem.Phys.Lipids_211_52 |
| ESTHER : Mateos-Diaz_2018_Chem.Phys.Lipids_211_52 |
| PubMedSearch : Mateos-Diaz_2018_Chem.Phys.Lipids_211_52 |
| PubMedID: 28235448 |
| Title : Efficient heterologous expression of Fusarium solani lipase, FSL2, in Pichia pastoris, functional characterization of the recombinant enzyme and molecular modeling - Jallouli_2016_Int.J.Biol.Macromol_94_61 |
| Author(s) : Jallouli R , Parsiegla G , Carriere F , Gargouri Y , Bezzine S |
| Ref : Int J Biol Macromol , 94 :61 , 2016 |
| Abstract : Jallouli_2016_Int.J.Biol.Macromol_94_61 |
| ESTHER : Jallouli_2016_Int.J.Biol.Macromol_94_61 |
| PubMedSearch : Jallouli_2016_Int.J.Biol.Macromol_94_61 |
| PubMedID: 27620466 |
| Gene_locus related to this paper: fushe-LIPASE |
| Title : A comparative study on two fungal lipases from Thermomyces lanuginosus and Yarrowia lipolytica shows the combined effects of detergents and pH on lipase adsorption and activity - Aloulou_2007_Biochim.Biophys.Acta_1771_1446 |
| Author(s) : Aloulou A , Puccinelli D , de Caro A , Leblond Y , Carriere F |
| Ref : Biochimica & Biophysica Acta , 1771 :1446 , 2007 |
| Abstract : Aloulou_2007_Biochim.Biophys.Acta_1771_1446 |
| ESTHER : Aloulou_2007_Biochim.Biophys.Acta_1771_1446 |
| PubMedSearch : Aloulou_2007_Biochim.Biophys.Acta_1771_1446 |
| PubMedID: 18022403 |
| Gene_locus related to this paper: humla-1lipa |
| Title : Val-407 and Ile-408 in the beta5'-loop of pancreatic lipase mediate lipase-colipase interactions in the presence of bile salt micelles - Freie_2006_J.Biol.Chem_281_7793 |
| Author(s) : Freie AB , Ferrato F , Carriere F , Lowe ME |
| Ref : Journal of Biological Chemistry , 281 :7793 , 2006 |
| Abstract : Freie_2006_J.Biol.Chem_281_7793 |
| ESTHER : Freie_2006_J.Biol.Chem_281_7793 |
| PubMedSearch : Freie_2006_J.Biol.Chem_281_7793 |
| PubMedID: 16431912 |
| Gene_locus related to this paper: human-PNLIP |
| Title : Hydrolysis of triacylglycerol arachidonic and linoleic acid ester bonds by human pancreatic lipase and carboxyl ester lipase - Chen_1989_Biochim.Biophys.Acta_1004_372 |
| Author(s) : Chen Q , Sternby B , Nilsson A |
| Ref : Biochimica & Biophysica Acta , 1004 :372 , 1989 |
| Abstract : Chen_1989_Biochim.Biophys.Acta_1004_372 |
| ESTHER : Chen_1989_Biochim.Biophys.Acta_1004_372 |
| PubMedSearch : Chen_1989_Biochim.Biophys.Acta_1004_372 |
| PubMedID: 2503032 |
| Title : Inhibition of human pancreatic lipase-colipase activity by mixed bile salt-phospholipid micelles - Patton_1981_Am.J.Physiol_241_G328 |
| Author(s) : Patton JS , Carey MC |
| Ref : American Journal of Physiology , 241 :G328 , 1981 |
| Abstract : Patton_1981_Am.J.Physiol_241_G328 |
| ESTHER : Patton_1981_Am.J.Physiol_241_G328 |
| PubMedSearch : Patton_1981_Am.J.Physiol_241_G328 |
| PubMedID: 7315970 |
| Title : On the binding of bile salt to pancreatic lipase - Borgstrom_1976_Biochim.Biophys.Acta_450_352 |
| Author(s) : Borgstrom B , Donner J |
| Ref : Biochimica & Biophysica Acta , 450 :352 , 1976 |
| Abstract : Borgstrom_1976_Biochim.Biophys.Acta_450_352 |
| ESTHER : Borgstrom_1976_Biochim.Biophys.Acta_450_352 |
| PubMedSearch : Borgstrom_1976_Biochim.Biophys.Acta_450_352 |
| PubMedID: 1009092 |
| Title : Inhibition of pancreatic lipase B activity by taurodeoxycholate and its reversal by colipase - Momsen_1976_J.Biol.Chem_251_384 |
| Author(s) : Momsen WE , Brockman HL |
| Ref : Journal of Biological Chemistry , 251 :384 , 1976 |
| Abstract : Momsen_1976_J.Biol.Chem_251_384 |
| ESTHER : Momsen_1976_J.Biol.Chem_251_384 |
| PubMedSearch : Momsen_1976_J.Biol.Chem_251_384 |
| PubMedID: 1245478 |