Type : Derivative of Tacrine,Acridine
Chemical_Nomenclature : (2E)-2-[(hydroxyamino)methylidene]-6-[4-(1,2,3,4-tetrahydroacridin-9-ylamino)butyl]pyridin-3-one
Canonical SMILES : C1CCC2=NC3=CC=CC=C3C(=C2C1)NCCCCC4=NC(=CNO)C(=O)C=C4
InChI : InChI=1S\/C23H26N4O2\/c28-22-13-12-16(26-21(22)15-25-29)7-5-6-14-24-23-17-8-1-3-10-19(17)27-20-11-4-2-9-18(20)23\/h1,3,8,10,12-13,15,28-29H,2,4-7,9,11,14H2,(H,24,27)\/b25-15+
InChIKey : WBLSVMZKFSZDDW-MFKUBSTISA-N || YQHRRIODIOINAV-RCCKNPSSSA-N
Other name(s) : 7.2.8. 2-[1-(Hydroxyimino)methyl]-6-{4-[(1,2,3,4-tetrahydroacridin-9-yl)amino]butyl}pyridin-3-ol,CHEMBL3234588,ZINC000169310262,SCHEMBL16712057,SCHEMBL18487408
MW :
Formula : C23H27N4O2
CAS_number :
PubChem : 90654886
UniChem : WBLSVMZKFSZDDW-MFKUBSTISA-N || YQHRRIODIOINAV-RCCKNPSSSA-N
IUPHAR :
Wikipedia :
Families : Tacrine-pyridinealdoxime-1 ligand of proteins in family: ACHE
Stucture :
Protein : torca-ACHE
Title : Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents - Santoni_2018_J.Med.Chem_61_7630 |
Author(s) : Santoni G , de Sousa J , De la Mora E , Dias J , Jean L , Sussman JL , Silman I , Renard PY , Brown RCD , Weik M , Baati R , Nachon F |
Ref : Journal of Medicinal Chemistry , 61 :7630 , 2018 |
Abstract : Santoni_2018_J.Med.Chem_61_7630 |
ESTHER : Santoni_2018_J.Med.Chem_61_7630 |
PubMedSearch : Santoni_2018_J.Med.Chem_61_7630 |
PubMedID: 30125110 |
Gene_locus related to this paper: torca-ACHE |
Title : Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase - Kliachyna_2014_Eur.J.Med.Chem_78C_455 |
Author(s) : Kliachyna M , Santoni G , Nussbaum V , Renou J , Sanson B , Colletier JP , Arboleas M , Loiodice M , Weik M , Jean L , Renard PY , Nachon F , Baati R |
Ref : Eur Journal of Medicinal Chemistry , 78C :455 , 2014 |
Abstract : Kliachyna_2014_Eur.J.Med.Chem_78C_455 |
ESTHER : Kliachyna_2014_Eur.J.Med.Chem_78C_455 |
PubMedSearch : Kliachyna_2014_Eur.J.Med.Chem_78C_455 |
PubMedID: 24704618 |