Tacrine-pentylmethylene-tolylsulfonamide
IC50 microM AChE 0.131 +/- 0.01 BChE 0.0680 +/- 0.0014
General
Type : Alkyl linked bis-ligand,Derivative of Tacrine,Sulfur Compound,Sulfonamide,Benzenesulfonamide
Chemical_Nomenclature : 4-Methyl-N-(5-(1,2,3,4-tetrahydro-acridin-9-ylamino)-pentyl)-benzenesulfonamide
Canonical SMILES : N(CCCCCN[S](=O)(=O)C1=CC=C(C=C1)C)C2=C4C(=NC3=CC=CC=C23)CCCC4
InChI : InChI=1S\/C25H31N3O2S\/c1-19-13-15-20(16-14-19)31(29,30)27-18-8-2-7-17-26-25-21-9-3-5-11-23(21)28-24-12-6-4-10-22(24)25\/h3,5,9,11,13-16,27H,2,4,6-8,10,12,17-18H2,1H3,(H,26,28)
InChIKey : AZQJBDNDDDGKPV-UHFFFAOYSA-N
Other name(s) : Compound 7h
MW : 437.59
Formula : C25H31N3O2S
CAS_number :
PubChem :
UniChem : AZQJBDNDDDGKPV-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : Tacrine-pentylmethylene-tolylsulfonamide ligand of proteins in family: ACHE || BCHE
Stucture :
Protein : human-ACHE || human-BCHE
References (1)
| Title : New Hybrids of 4-Amino-2,3-polymethylene-quinoline and p-Tolylsulfonamide as Dual Inhibitors of Acetyl- and Butyrylcholinesterase and Potential Multifunctional Agents for Alzheimer's Disease Treatment - Makhaeva_2020_Molecules_25_3915 |
| Author(s) : Makhaeva GF , Kovaleva NV , Boltneva NP , Lushchekina SV , Astakhova TY , Rudakova EV , Proshin AN , Serkov IV , Radchenko EV , Palyulin VA , Bachurin SO , Richardson RJ |
| Ref : Molecules , 25 :3915 , 2020 |
| Abstract : Makhaeva_2020_Molecules_25_3915 |
| ESTHER : Makhaeva_2020_Molecules_25_3915 |
| PubMedSearch : Makhaeva_2020_Molecules_25_3915 |
| PubMedID: 32867324 |