TFAH-tacrine-ferulic-acid-hybrid-10n
BCHE IC50=68.2 nM
General
Type : Multitarget,Acrylate,Antioxidant,Derivative of Tacrine,Hydroxycinnamic-ester,Alkyl linked bis-ligand
Chemical_Nomenclature : (E)-3-(4-hydroxy-3-methoxyphenyl)-N-[8-[(7-methoxy-1,2,3,4-tetrahydroacridin-9-yl)amino]octyl]-N-[2-(naphthalen-2-ylamino)-2-oxoethyl]prop-2-enamide
Canonical SMILES : COC1=CC2=C(C=C1)N=C3CCCCC3=C2NCCCCCCCCN(CC(=O)NC4=CC5=CC=CC=C5C=C4)C(=O)C=CC6=CC(=C(C=C6)O)OC
InChI : InChI=1S\/C44H50N4O5\/c1-52-35-21-22-39-37(29-35)44(36-15-9-10-16-38(36)47-39)45-25-11-5-3-4-6-12-26-48(43(51)24-18-31-17-23-40(49)41(27-31)53-2)30-42(50)46-34-20-19-32-13-7-8-14-33(32)28-34\/h7-8,13-14,17-24,27-29,49H,3-6,9-12,15-16,25-26,30H2,1-2H3,(H,45,47)(H,46,50)\/b24-18+
InChIKey : CIMNCRAYKQYYMB-HKOYGPOVSA-N
Other name(s) : (E)-3-(hydroxy-3-methoxyphenyl)-N-{8[(7-methoxy-1,2,3,4-tetrahydroacridin-9-yl)amino]octyl}-N-[2-(naphthalen-2-ylamino)2-oxoethyl]acrylamide,CHEMBL4552675,BDBM50510850
MW : 714.9
Formula : C44H50N4O5
CAS_number :
PubChem : 132281442
UniChem : CIMNCRAYKQYYMB-HKOYGPOVSA-N
IUPHAR :
Wikipedia :
Target
Families : TFAH-tacrine-ferulic-acid-hybrid-10n ligand of proteins in family: BCHE
Stucture :
Protein :
References (1)
| Title : Novel tacrine-grafted ugi adducts as multipotent anti-Alzheimer drugs: a synthetic renewal in tacrine-ferulic Acid hybrids - Benchekroun_2015_ChemMedChem_10_523 |
| Author(s) : Benchekroun M , Bartolini M , Egea J , Romero A , Soriano E , Pudlo M , Luzet V , Andrisano V , Jimeno ML , Lopez MG , Wehle S , Gharbi T , Refouvelet B , de Andres L , Herrera-Arozamena C , Monti B , Bolognesi ML , Rodriguez-Franco MI , Decker M , Marco-Contelles J , Ismaili L |
| Ref : ChemMedChem , 10 :523 , 2015 |
| Abstract : Benchekroun_2015_ChemMedChem_10_523 |
| ESTHER : Benchekroun_2015_ChemMedChem_10_523 |
| PubMedSearch : Benchekroun_2015_ChemMedChem_10_523 |
| PubMedID: 25537267 |