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Inhibitor Report for: Sulfapyridine

Not inhibitor of Notum. Compound 11 Fragment 151 IC50 >1000 microM. Sulfapyridine is a short-acting sulfonamide antibiotic and by-product of the non-steroidal anti-inflammatory drug sulfasalazine. Its manufacture and use were discontinued in 1990


General
Type Fragment inhibitor of Notum, Sulfonamide, Sulfur Compound, Antibiotic, Pyridine, Not A/B H target, Benzenesulfonamide
Chemical_Nomenclature 4-amino-N-pyridin-2-ylbenzenesulfonamide
Canonical SMILES C1=CC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N
InChI InChI=1S/C11H11N3O2S/c12-9-4-6-10(7-5-9)17(15,16)14-11-3-1-2-8-13-11/h1-8H,12H2,(H,13,14)
InChIKey GECHUMIMRBOMGK-UHFFFAOYSA-N
Other name(s) Fragment 151 ; Fragment-151 ; SFY ; DB00891 ; Sulphapyridine ; 2-Sulfapyridine ; Sulfidin ; CHEBI:132842 ; CHEMBL700 ; Oprea1_344996 ; SCHEMBL44219 ; ZINC2105
________________________________________________________________________________________________
MW|249.29
Formula|C11H11N3O2S
CAS_number|144-83-2
PubChem|5336
UniChem|GECHUMIMRBOMGK-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | Sulfapyridine ligand of proteins in family: Pectinacetylesterase-Notum
Stucture | 1 structure: 7B8D: Structure of the human Wnt deacylase Notum in complex with (fragment 151) Sulfapyridine
Protein | human-NOTUM

References:
Search PubMed for references concerning: Sulfapyridine
    Title: Structural Analysis and Development of Notum Fragment Screening Hits
    Zhao Y, Mahy W, Willis NJ, Woodward HL, Steadman D, Bayle ED, Atkinson BN, Sipthorp J, Vecchia L and Jones EY <11 more author(s)>
    Ref: ACS Chem Neurosci, 13:2060, 2022 : PubMed