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Inhibitor Report for: Spermidine

Spermidine is a polyamine formed from putrescine. It is found in almost all tissues in association with nucleic acids. It is found as a cation at all pH values, and is thought to help stabilize some membranes and nucleic acid structures. It is a precursor of spermine. Inhibits some lipases CarbLipBact_2 or moderately activates others


General
Type Natural
Chemical_Nomenclature N'-(3-aminopropyl)butane-1,4-diamine
Canonical SMILES C(CCNCCCN)CN
InChI InChI=1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2
InChIKey ATHGHQPFGPMSJY-UHFFFAOYSA-N
Other name(s) 1,5,10-Triazadecane ; 4-Azaoctamethylenediamine ; Spermidin ; 4-Azaoctane-1,8-diamine
________________________________________________________________________________________________
MW|145.25
Formula|C7H19N3
CAS_number|124-20-9
PubChem|1102
UniChem|ATHGHQPFGPMSJY-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | Spermidine ligand of proteins in family: CarbLipBact_2
Stucture | 1 structure: 4FBL: LipS and LipT, two metagenome-derived lipolytic enzymes increase the diversity of known lipase and esterase families 1. This is LipS
Protein | symth-q67mr3

References:
Search PubMed for references concerning: Spermidine
    Title: CGI-58, a key regulator of lipid homeostasis and signaling in plants, also regulates polyamine metabolism
    Park S, Keereetaweep J, James CN, Gidda SK, Chapman KD, Mullen RT, Dyer JM
    Ref: Plant Signal Behav, 9:e27723, 2014 : PubMed

            

    Title: The metagenome-derived enzymes LipS and LipT increase the diversity of known lipases
    Chow J, Kovacic F, Dall Antonia Y, Krauss U, Fersini F, Schmeisser C, Lauinger B, Bongen P, Pietruszka J and Streit WR <8 more author(s)>
    Ref: PLoS ONE, 7:e47665, 2012 : PubMed

            

    Title: Cloning, expression, purification and preliminary X-ray analysis of a putative metagenome-derived lipase
    Fersini F, Dall'Antonia Y, Chow J, Streit WR, Mueller-Dieckmann J
    Ref: Acta Crystallographica Sect F Struct Biol Cryst Commun, 68:923, 2012 : PubMed