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Inhibitor Report for: Sarin

The organophosphate nerve agents tabun (GA), sarin (GB), soman (GD), and cyclosarin (GF) are among the most toxic chemical warfare agents known. The G-series nerve agents are named because German scientists led by Dr Gerhard Schraderfirst synthesized them during World War II, beginning with GA in 1936. GB was discovered next in 1938, followed by GD in 1944 and finally GF in 1949. The only other known nerve agent, O-ethyl S-(2-diisopropylaminoethyl) methylphosphonothioate (VX), V-series - VE, VG, VM, Russian VX). G-series nerve agents share a number of common physical and chemical properties. At room temperature, the G-series nerve agents are volatile liquids, making them a serious risk for 2 types of exposure: dermal contact with liquid nerve agent or inhalation of nerve agent vapor.Sarin is an acronym for the names of the members of the development team: Schrader. Ambrose. Rudriger. and van der Linde. The Germans deignated it T-I44 or Trilon-46. The United Slates eventually designated it GB


General
Type Chemical Warfare Agent, Organophosphate, Nerve Agent G-series, Derivative of Sarin
Chemical_Nomenclature 2-[fluoro(methyl)phosphoryl]oxypropane
Canonical SMILES CC(C)OP(=O)(C)F
InChI InChI=1S/C4H10FO2P/c1-4(2)7-8(3,5)6/h4H,1-3H3
InChIKey DYAHQFWOVKZOOW-UHFFFAOYSA-N
Other name(s) Zarin ; Sarin II ; Trilone 46 ; IMPF ; Methylphosphonofluoridic acid 1-methyl-ethyl esther ; Isopropylmethylphosphonofluoridate ; Isopropoxymethylphosphorylfluoride ; GB ; T144 ; T-144 ; Trilon-46
________________________________________________________________________________________________
MW|140.09
Formula|C4H10FO2P
CAS_number|107-44-8
PubChem|7871
UniChem|DYAHQFWOVKZOOW-UHFFFAOYSA-N
IUPHAR|
Wikipedia|Sarin

Target
Families | Sarin ligand of proteins in family: ACHE, BCHE, PAF-Acetylhydrolase, Carboxypeptidase_S10
Stucture | 12 structures (e.g. : 1CFJ, 7R0A, 7BFU... more)
Protein | human-ACHE, human-BCHE, human-CTSA

References:
Search PubMed for references concerning: Sarin

45 more
    Title: Covalent inhibition of hAChE by organophosphates causes homodimer dissociation through long-range allosteric effects
    Blumenthal DK, Cheng X, Fajer M, Ho KY, Rohrer J, Gerlits O, Taylor P, Juneja P, Kovalevsky A, Radic Z
    Ref: Journal of Biological Chemistry, :101007, 2021 : PubMed

            

    Title: Enzymatic Decontamination of G-Type, V-Type and Novichok Nerve Agents
    Jacquet P, Remy B, Bross RPT, van Grol M, Gaucher F, Chabriere E, De Koning MC, Daude D
    Ref: Int J Mol Sci, 22:, 2021 : PubMed

            

    Title: Structural and Biochemical Insights into the Inhibition of Human Acetylcholinesterase by G-Series Nerve Agents and Subsequent Reactivation by HI-6
    McGuire JR, Bester SM, Guelta MA, Cheung J, Langley C, Winemiller MD, Bae SY, Funk V, Myslinski JM and Height JJ <1 more author(s)>
    Ref: Chemical Research in Toxicology, 34:804, 2021 : PubMed