SR-4995
Directly binds ABHD5 and stimulate lipolysis by releasing it from PLIN, thereby mimicking the effects of extracellular signaling in the absence of PKA-dependent phosphorylation of HSL and PLIN
General
Type : Urea derivative,Sulfur Compound,Benzothiazepine,Azepine
Chemical_Nomenclature : 1-butyl-3-(5-methyl-6-oxobenzo[b][1,4]benzothiazepin-3-yl)urea
Canonical SMILES : CCCCNC(=O)NC1=CC2=C(C=C1)SC3=CC=CC=C3C(=O)N2C
InChI : InChI=1S\/C19H21N3O2S\/c1-3-4-11-20-19(24)21-13-9-10-17-15(12-13)22(2)18(23)14-7-5-6-8-16(14)25-17\/h5-10,12H,3-4,11H2,1-2H3,(H2,20,21,24)
InChIKey : UGYXUEPBYOKNOL-UHFFFAOYSA-N
Other name(s) : SR4995,MLS001200212,SMR000563557,N-butyl-N'-(10-methyl-11-oxo-10,11-dihydrodibenzo[b,f][1,4]thiazepin-8-yl)urea,SR-01000804995
MW : 355.5
Formula : C19H21N3O2S
CAS_number :
PubChem : 16016685
UniChem : UGYXUEPBYOKNOL-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : SR-4995 ligand of proteins in family: CGI-58_ABHD5_ABHD4
Stucture :
Protein : human-ABHD5 || mouse-abhd5
References (2)
| Title : Novel Pharmacological Probes Reveal ABHD5 as a Locus of Lipolysis Control in White and Brown Adipocytes - Rondini_2017_J.Pharmacol.Exp.Ther_363_367 |
| Author(s) : Rondini EA , Mladenovic-Lucas L , Roush WR , Halvorsen GT , Green AE , Granneman JG |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 363 :367 , 2017 |
| Abstract : Rondini_2017_J.Pharmacol.Exp.Ther_363_367 |
| ESTHER : Rondini_2017_J.Pharmacol.Exp.Ther_363_367 |
| PubMedSearch : Rondini_2017_J.Pharmacol.Exp.Ther_363_367 |
| PubMedID: 28928121 |
| Gene_locus related to this paper: human-ABHD5 , mouse-abhd5 |
| Title : Endogenous and Synthetic ABHD5 Ligands Regulate ABHD5-Perilipin Interactions and Lipolysis in Fat and Muscle - Sanders_2015_Cell.Metab_22_851 |
| Author(s) : Sanders MA , Madoux F , Mladenovic L , Zhang H , Ye X , Angrish M , Mottillo EP , Caruso JA , Halvorsen G , Roush WR , Chase P , Hodder P , Granneman JG |
| Ref : Cell Metab , 22 :851 , 2015 |
| Abstract : Sanders_2015_Cell.Metab_22_851 |
| ESTHER : Sanders_2015_Cell.Metab_22_851 |
| PubMedSearch : Sanders_2015_Cell.Metab_22_851 |
| PubMedID: 26411340 |
| Gene_locus related to this paper: human-ABHD5 , mouse-abhd5 |