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Russian-VX

Similar to VX

General

Type : Chemical Warfare Agent,Organophosphate,Nerve Agent V-series,Sulfur Compound

Chemical_Nomenclature : S-(N,N-diethylaminoethyl) isobutyl methylphosphothiolate

Canonical SMILES : CCN(CC)CCSP(=O)(C)OCC(C)C

InChI : InChI=1S\/C11H26NO2PS\/c1-6-12(7-2)8-9-16-15(5,13)14-10-11(3)4\/h11H,6-10H2,1-5H3

InChIKey : MNLAVFKVRUQAKW-UHFFFAOYSA-N

Other name(s) : S-[2-(diethylamino)ethyl] O-2-methylpropyl ester,VR nerve agent,Russian VX,R-VX,RVX,V-gas,S-(N,N-DEA)IMPT,VR,R 33,R-33,Substance-33,Substance 33

MW : 267.368

Formula : C11H26NO2PS

CAS_number : 159939-87-4

PubChem : 178033

UniChem : MNLAVFKVRUQAKW-UHFFFAOYSA-N

Target

Families : Russian-VX ligand of proteins in family
ACHE BCHE

Protein :
mouse-ACHE human-BCHE

References (14)

Title : The prediction of acute toxicity (LD(50)) for organophosphorus-based chemical warfare agents (V-series) using toxicology in silico methods - Noga_2023_Arch.Toxicol__
Author(s) : Noga M , Michalska A , Jurowski K
Ref : Archives of Toxicology , : , 2023
Abstract : Noga_2023_Arch.Toxicol__
ESTHER : Noga_2023_Arch.Toxicol__
PubMedSearch : Noga_2023_Arch.Toxicol__
PubMedID: 38051368

Title : Novichok agents: a historical, current, and toxicological perspective - Chai_2018_Toxicol.Commun_2_45
Author(s) : Chai PR , Hayes BD , Erickson TB , Boyer EW
Ref : Toxicol Commun , 2 :45 , 2018
Abstract : Chai_2018_Toxicol.Commun_2_45
ESTHER : Chai_2018_Toxicol.Commun_2_45
PubMedSearch : Chai_2018_Toxicol.Commun_2_45
PubMedID: 30003185

Title : Determination of the structural features of O-alkyl-S-2-(N,N-dialkylamino) ethyl alkylthiophosphonates from their electron ionization mass spectra - Terentyev_2016_J.Anal.Chem_71_1266
Author(s) : Terentyev AG , Morozik YI , Rybal'chenko IV , Dudkin AV , Smirnov AO , Galyaev GV
Ref : Journal of Analytical Chemistry , 71 :1266 , 2016
Abstract : Terentyev_2016_J.Anal.Chem_71_1266
ESTHER : Terentyev_2016_J.Anal.Chem_71_1266
PubMedSearch : Terentyev_2016_J.Anal.Chem_71_1266
PubMedID:

Title : Catalytic-site conformational equilibrium in nerve-agent adducts of acetylcholinesterase: possible implications for the HI-6 antidote substrate specificity - Artursson_2013_Biochem.Pharmacol_85_1389
Author(s) : Artursson E , Andersson PO , Akfur C , Linusson A , Borjegren S , Ekstrom F
Ref : Biochemical Pharmacology , 85 :1389 , 2013
Abstract : Artursson_2013_Biochem.Pharmacol_85_1389
ESTHER : Artursson_2013_Biochem.Pharmacol_85_1389
PubMedSearch : Artursson_2013_Biochem.Pharmacol_85_1389
PubMedID: 23376121
Gene_locus related to this paper: mouse-ACHE

Title : Microplate biochemical determination of Russian VX: influence of admixtures and avoidance of false negative results - Prokofieva_2012_Anal.Biochem_424_108
Author(s) : Prokofieva DS , Jenkins RO , Goncharov NV
Ref : Analytical Biochemistry , 424 :108 , 2012
Abstract : Prokofieva_2012_Anal.Biochem_424_108
ESTHER : Prokofieva_2012_Anal.Biochem_424_108
PubMedSearch : Prokofieva_2012_Anal.Biochem_424_108
PubMedID: 22381367

Title : Immobilization of Russian VX skin depots by localized cooling: implications for decontamination and medical countermeasures - Mikler_2011_Toxicol.Lett_206_47
Author(s) : Mikler J , Tenn C , Worek F , Reiter G , Thiermann H , Garrett M , Bohnert S , Sawyer TW
Ref : Toxicol Lett , 206 :47 , 2011
Abstract : Mikler_2011_Toxicol.Lett_206_47
ESTHER : Mikler_2011_Toxicol.Lett_206_47
PubMedSearch : Mikler_2011_Toxicol.Lett_206_47
PubMedID: 21704135

Title : Human serum butyrylcholinesterase as a prophylaxis against russian VX - Karasova_2011_Mil.Med.Sci.Lett_80_97
Author(s) : Karasova JZ , Kuca K , Jun D , Bajgar J
Ref : Military Medical Science Letters , 80 :97 , 2011
Abstract : Karasova_2011_Mil.Med.Sci.Lett_80_97
ESTHER : Karasova_2011_Mil.Med.Sci.Lett_80_97
PubMedSearch : Karasova_2011_Mil.Med.Sci.Lett_80_97
PubMedID:

Title : Different inhibition of acetylcholinesterase in selected parts of the rat brain following intoxication with VX and Russian VX - Hajek_2009_Drug.Chem.Toxicol_32_1
Author(s) : Hajek P , Bajgar J , Slizova D , Krs O , Kuca K , Capek L , Fusek J
Ref : Drug & Chemical Toxicology , 32 :1 , 2009
Abstract : Hajek_2009_Drug.Chem.Toxicol_32_1
ESTHER : Hajek_2009_Drug.Chem.Toxicol_32_1
PubMedSearch : Hajek_2009_Drug.Chem.Toxicol_32_1
PubMedID: 19514933

Title : Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX - Karasova_2009_Neurotox.Res_16_356
Author(s) : Karasova JZ , Bajgar J , Jun D , Pavlikova R , Kuca K
Ref : Neurotox Res , 16 :356 , 2009
Abstract : Karasova_2009_Neurotox.Res_16_356
ESTHER : Karasova_2009_Neurotox.Res_16_356
PubMedSearch : Karasova_2009_Neurotox.Res_16_356
PubMedID: 19728005

Title : Evaluation of potency of known oximes (pralidoxime, trimedoxime, HI-6, methoxime, obidoxime) to in vitro reactivate acetylcholinesterase inhibited by pesticides (chlorpyrifos and methylchlorpyrifos) and nerve agent (Russian VX) - Musilek_2007_Acta.Medica.(Hradec.Kralove)_50_203
Author(s) : Musilek K , Kuca K , Jun D
Ref : Acta Medica (Hradec Kralove) , 50 :203 , 2007
Abstract : Musilek_2007_Acta.Medica.(Hradec.Kralove)_50_203
ESTHER : Musilek_2007_Acta.Medica.(Hradec.Kralove)_50_203
PubMedSearch : Musilek_2007_Acta.Medica.(Hradec.Kralove)_50_203
PubMedID: 18254274

Title : The Reactivating and Therapeutic Efficacy of Oximes to Counteract Russian VX Poisonings - Kassa_2006_Int.J.Toxicol_25_397
Author(s) : Kassa J , Jun D , Kuca K
Ref : Int J Toxicol , 25 :397 , 2006
Abstract : Kassa_2006_Int.J.Toxicol_25_397
ESTHER : Kassa_2006_Int.J.Toxicol_25_397
PubMedSearch : Kassa_2006_Int.J.Toxicol_25_397
PubMedID: 16940011

Title : Russian VX: inhibition and reactivation of acetylcholinesterase compared with VX agent - Kuca_2006_Basic.Clin.Pharmacol.Toxicol_98_389
Author(s) : Kuca K , Jun D , Cabal J , Hrabinova M , Bartosova L , Opletalova V
Ref : Basic Clin Pharmacol Toxicol , 98 :389 , 2006
Abstract : Kuca_2006_Basic.Clin.Pharmacol.Toxicol_98_389
ESTHER : Kuca_2006_Basic.Clin.Pharmacol.Toxicol_98_389
PubMedSearch : Kuca_2006_Basic.Clin.Pharmacol.Toxicol_98_389
PubMedID: 16623863

Title : Oxidative biodegradation of phosphorothiolates by fungal laccase - Amitai_1998_FEBS.Lett_438_195
Author(s) : Amitai G , Adani R , Sod-Moriah G , Rabinovitz I , Vincze A , Leader H , Chefetz B , Leibovitz-Persky L , Friesem D , Hadar Y
Ref : FEBS Letters , 438 :195 , 1998
Abstract : Amitai_1998_FEBS.Lett_438_195
ESTHER : Amitai_1998_FEBS.Lett_438_195
PubMedSearch : Amitai_1998_FEBS.Lett_438_195
PubMedID: 9827544

Title : Enzymatic hydrolysis of Russian-VX by organophosphorus hydrolase - Rastogi_1997_Biochem.Biophys.Res.Commun_241_294
Author(s) : Rastogi VK , DeFrank JJ , Cheng TC , Wild JR
Ref : Biochemical & Biophysical Research Communications , 241 :294 , 1997
Abstract : Rastogi_1997_Biochem.Biophys.Res.Commun_241_294
ESTHER : Rastogi_1997_Biochem.Biophys.Res.Commun_241_294
PubMedSearch : Rastogi_1997_Biochem.Biophys.Res.Commun_241_294
PubMedID: 9425265 
Array
(
    [id] => 5760
    [inhibitor] => Russian-VX
    [type] => Array
        (
            [0] => Chemical Warfare Agent
            [1] => Organophosphate
            [2] => Nerve Agent V-series
            [3] => Sulfur Compound
        )

    [other_name] => Array
        (
            [0] => S-[2-(diethylamino)ethyl] O-2-methylpropyl ester
            [1] => VR nerve agent
            [2] => Russian VX
            [3] => R-VX
            [4] => RVX
            [5] => V-gas
            [6] => S-(N,N-DEA)IMPT
            [7] => VR
            [8] => R 33
            [9] => R-33
            [10] => Substance-33
            [11] => Substance 33
        )

    [chemical_nomenclature] => S-(N,N-diethylaminoethyl) isobutyl methylphosphothiolate
    [formula] => C11H26NO2PS
    [cas_number] => 159939-87-4
    [mw] => 267.368
    [pick_me_to_call] => display_script
    [kinetic_parameter] => 
    [paper] => Rastogi_1997_Biochem.Biophys.Res.Commun_241_294 || Artursson_2013_Biochem.Pharmacol_85_1389 || Hajek_2009_Drug.Chem.Toxicol_32_1 || Karasova_2009_Neurotox.Res_16_356 || Kassa_2006_Int.J.Toxicol_25_397 || Kuca_2006_Basic.Clin.Pharmacol.Toxicol_98_389 || Mikler_2011_Toxicol.Lett_206_47 || Musilek_2007_Acta.Medica.(Hradec.Kralove)_50_203 || Prokofieva_2012_Anal.Biochem_424_108 || Amitai_1998_FEBS.Lett_438_195 || Terentyev_2016_J.Anal.Chem_71_1266 || Karasova_2011_Mil.Med.Sci.Lett_80_97 || Chai_2018_Toxicol.Commun_2_45 || Noga_2023_Arch.Toxicol__
    [comment] => Similar to VX
    [gene_locus] => mouse-ACHE || human-BCHE
    [kin_inhibitor] => 
    [cid] => 178033
    [family] => ACHE || BCHE
    [inchikey] => MNLAVFKVRUQAKW-UHFFFAOYSA-N
    [canonicalsmiles] => CCN(CC)CCSP(=O)(C)OCC(C)C
    [inchi] => InChI=1S\/C11H26NO2PS\/c1-6-12(7-2)8-9-16-15(5,13)14-10-11(3)4\/h11H,6-10H2,1-5H3
    [wikipedia] => 
    [iupharlig] => 
    [structure] => 
    [substrate] => 
    [interact_gene_locus] => 
    [mutation] => 
    [comment2] => 
    [extoxnet] => 
    [news] => 
    [theoretical_model] => 
)